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- Publications
- Influence
The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s…
- M. Albert, S. DeKosky, +11 authors C. Phelps
- Medicine, Psychology
- 2011
The National Institute on Aging and the Alzheimer’s Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer’s disease (AD), referred to… Expand
Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory.
- D. Kaufer, J. Cummings, +5 authors S. DeKosky
- Psychology, Medicine
- The Journal of neuropsychiatry and clinical…
- 1 May 2000
The Neuropsychiatric Inventory (NPI) is a validated clinical instrument for evaluating psychopathology in dementia. The authors developed a brief questionnaire form of the NPI (NPI-Q), intended for… Expand
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study.
- C. Lyketsos, O. López, B. Jones, A. Fitzpatrick, J. Breitner, S. DeKosky
- Medicine
- JAMA
- 25 September 2002
CONTEXT
Mild cognitive impairment (MCI) may be a precursor to dementia, at least in some cases. Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2… Expand
Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review)
- R. Petersen, J. Stevens, M. Ganguli, E. Tangalos, J. Cummings, S. DeKosky
- Psychology, Medicine
- Neurology
- 8 May 2001
Objective: The goal of this project was to determine whether screening different groups of elderly individuals in a general or specialty practice would be beneficial in detecting dementia.… Expand
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
- A. Naj, G. Jun, +152 authors G. Schellenberg
- Biology, Medicine
- Nature Genetics
- 3 April 2011
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two… Expand
Practice parameter: Diagnosis of dementia (an evidence-based review)
- D. Knopman, S. DeKosky, +6 authors J. Stevens
- Medicine
- Neurology
- 8 May 2001
Objective: To update the 1994 practice parameter for the diagnosis of dementia in the elderly. Background: The AAN previously published a practice parameter on dementia in 1994. New research and… Expand
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
- S. DeKosky, S. Scheff
- Medicine
- Annals of neurology
- 1 May 1990
Ultrastructural studies of biopsied cortical tissue from the right frontal lobe of 8 patients with mild to moderate Alzheimer's disease (AD) revealed that the number of synapses in lamina III of… Expand
[11C]PIB in a nondemented population
- M. Mintun, G. LaRossa, +7 authors J. Morris
- Psychology, Medicine
- Neurology
- 8 August 2006
Background: Beta-amyloid (Aβ) plaques are the hallmark of Alzheimer disease (AD). A PET imaging tracer that binds to Aβ plaques in vivo, N-methyl-[11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole… Expand
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
- M. Ikonomovic, W. Klunk, +12 authors S. DeKosky
- Chemistry, Medicine
- Brain : a journal of neurology
- 12 March 2008
The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ) peptide in vitro. The in vivo retention of… Expand
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
- J. Price, W. Klunk, +7 authors C. Mathis
- Medicine, Psychology
- Journal of cerebral blood flow and metabolism…
- 8 June 2005
A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our group developed… Expand