cholesterol 24-hydroxylase

Known as: Cholesterol 24 Hydroxylase, Brain Specific 24S Hydroxylase, Brain-Specific 24S-Hydroxylase 
A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2016
024619992016

Papers overview

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2014
2014
Oxysterols are oxidised forms of cholesterol or its precursors. In this study we utilised the cholesterol 24-hydroxylase knockout… (More)
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2009
2009
The mechanistic basis for the tissue specific expression of cholesterol elimination pathways is poorly understood. To gain… (More)
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2008
2008
Cholesterol 24-hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the… (More)
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2006
2006
Mammalian CNS contains a disproportionally large and remarkably stable pool of cholesterol. Despite an efficient recycling there… (More)
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Highly Cited
2006
Highly Cited
2006
The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of… (More)
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2004
2004
Cholesterol is eliminated from neurons by oxidization, which generates oxysterols. Cholesterol oxidation is mediated by the… (More)
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Highly Cited
2003
Highly Cited
2003
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted… (More)
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2003
2003
Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the… (More)
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2002
2002
Alzheimer's disease (AD) is a complex, multifactorial disorder, with many genetic and environmental factors implicated in disease… (More)
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Highly Cited
1999
Highly Cited
1999
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an… (More)
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