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cholesterol 24-hydroxylase

Known as: Cholesterol 24 Hydroxylase, Brain Specific 24S Hydroxylase, Brain-Specific 24S-Hydroxylase 
A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is… Expand
National Institutes of Health

Papers overview

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2014
2014
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2013
2013
Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP… Expand
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2010
2010
Maintaining the cholesterol homeostasis is essential for normal CNS functioning. The enzyme responsible for elimination of… Expand
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Highly Cited
2008
Highly Cited
2008
Cholesterol 24-hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the… Expand
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2008
2008
Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during… Expand
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2004
2004
An association was recently reported between an increased risk of Alzheimer's disease and an intron 2 AA genotype of CYP46, the… Expand
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Highly Cited
2003
Highly Cited
2003
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby… Expand
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2002
2002
Alzheimer's disease (AD) is a complex, multifactorial disorder, with many genetic and environmental factors implicated in disease… Expand
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Highly Cited
1999
Highly Cited
1999
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an… Expand
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