FAQ

cholesterol 24-hydroxylase

Known as: Cholesterol 24 Hydroxylase, Brain Specific 24S Hydroxylase, Brain-Specific 24S-Hydroxylase 
A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2016
024619992016

Related topics

Related topics

14 relations
CYP46A1 geneIn BloodProcess of secretionadministration & dosage
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Narrower (2)

Cholestane Tetrol 24-HydroxylaseCytochrome P450 46A1

Broader (1)

Cytochrome P450 Family 46

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
cholesterol 24-hydroxylase
physiological aspects
chemical synthesis
standards characteristics
Process of secretion
Cytochrome P450 46A1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse
Oxysterols are oxidised forms of cholesterol or its precursors. In this study we utilised the cholesterol 24-hydroxylase knockout… (More)
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2009
2009
Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors.
The mechanistic basis for the tissue specific expression of cholesterol elimination pathways is poorly understood. To gain… (More)
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2008
2008
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain.
Cholesterol 24-hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the… (More)
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2006
2006
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
Mammalian CNS contains a disproportionally large and remarkably stable pool of cholesterol. Despite an efficient recycling there… (More)
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Highly Cited
2006
Highly Cited
2006
Brain cholesterol turnover required for geranylgeraniol production and learning in mice.
The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of… (More)
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2004
2004
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Cholesterol is eliminated from neurons by oxidization, which generates oxysterols. Cholesterol oxidation is mediated by the… (More)
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Highly Cited
2003
Highly Cited
2003
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted… (More)
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2003
2003
Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration.
Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the… (More)
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2002
2002
Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease.
Alzheimer's disease (AD) is a complex, multifactorial disorder, with many genetic and environmental factors implicated in disease… (More)
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Highly Cited
1999
Highly Cited
1999
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an… (More)
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