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cholesterol 24-hydroxylase

Known as: Cholesterol 24 Hydroxylase, Brain Specific 24S Hydroxylase, Brain-Specific 24S-Hydroxylase 
A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is… Expand
National Institutes of Health

Related topics

Related topics

12 relations
CYP46A1 geneIn BloodProcess of secretionantagonists & inhibitors
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Narrower (2)

Cholestane Tetrol 24-HydroxylaseCytochrome P450 46A1

Broader (1)

Cytochrome P450 Family 46

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse
Graphical abstract 
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Highly Cited
2008
Highly Cited
2008
Neuronal expression and subcellular localization of cholesterol 24‐hydroxylase in the mouse brain
Cholesterol 24‐hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the… Expand
Highly Cited
2008
Highly Cited
2008
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro.
Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during… Expand
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2004
2004
Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer’s disease
An association was recently reported between an increased risk of Alzheimer's disease and an intron 2 AA genotype of CYP46, the… Expand
Review
2004
Review
2004
Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer’s disease
Mechanisms for the regulation of intracellular cholesterol levels in various types of brain and vascular cells are of… Expand
Highly Cited
2003
Highly Cited
2003
Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover*
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted… Expand
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Highly Cited
2003
Highly Cited
2003
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.
BACKGROUND CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby… Expand
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Highly Cited
2002
Highly Cited
2002
Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
Alzheimer's disease (AD) is a complex, multifactorial disorder, with many genetic and environmental factors implicated in disease… Expand
Highly Cited
1999
Highly Cited
1999
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an… Expand
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Review
1999
Review
1999
Removal of cholesterol from extrahepatic sources by oxidative mechanisms.
Sterol 27-hydroxylase is an evolutionarily old cytochrome P450 species that is critical for oxidation of the side chain of… Expand
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