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cholesterol 24-hydroxylase

Known as: Cholesterol 24 Hydroxylase, Brain Specific 24S Hydroxylase, Brain-Specific 24S-Hydroxylase 
A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is… Expand
National Institutes of Health

Papers overview

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2014
2014
Graphical abstract 
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Highly Cited
2008
Highly Cited
2008
Cholesterol 24‐hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the… Expand
Highly Cited
2008
Highly Cited
2008
Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during… Expand
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2004
2004
An association was recently reported between an increased risk of Alzheimer's disease and an intron 2 AA genotype of CYP46, the… Expand
Review
2004
Review
2004
Mechanisms for the regulation of intracellular cholesterol levels in various types of brain and vascular cells are of… Expand
Highly Cited
2003
Highly Cited
2003
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby… Expand
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Highly Cited
2002
Highly Cited
2002
Alzheimer's disease (AD) is a complex, multifactorial disorder, with many genetic and environmental factors implicated in disease… Expand
Highly Cited
1999
Highly Cited
1999
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an… Expand
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Review
1999
Review
1999
Sterol 27-hydroxylase is an evolutionarily old cytochrome P450 species that is critical for oxidation of the side chain of… Expand