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CpG Islands

Known as: CpG island, CpG-Rich Islands, CpG-Rich Island 
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several… Expand
National Institutes of Health

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Review
2011
Review
2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by… Expand
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Highly Cited
2009
Highly Cited
2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… Expand
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Highly Cited
2006
Highly Cited
2006
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing… Expand
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Highly Cited
2002
Highly Cited
2002
  • D. Takai, P. Jones
  • Proceedings of the National Academy of Sciences…
  • 2002
  • Corpus ID: 23608192
CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their genomes. In addition, CpG islands… Expand
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Highly Cited
2000
Highly Cited
2000
CpG islands frequently contain gene promoters or exons and are usually unmethylated in normal cells. Methylation of CpG islands… Expand
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… Expand
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Highly Cited
1996
Highly Cited
1996
Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes… Expand
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Highly Cited
1995
Highly Cited
1995
Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of… Expand
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Highly Cited
1993
Highly Cited
1993
Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study… Expand
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Highly Cited
1987
Highly Cited
1987
Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been shown that some vertebrate genes… Expand
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