CpG Islands

Known as: CpG island, CpG-Rich Islands, CpG-Rich Island 
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was… (More)
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Review
2011
Review
2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by… (More)
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Highly Cited
2009
Highly Cited
2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… (More)
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Review
2009
Review
2009
Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs… (More)
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Highly Cited
2006
Highly Cited
2006
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing… (More)
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Highly Cited
2002
Highly Cited
2002
CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their genomes. In addition, CpG islands… (More)
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Highly Cited
2000
Highly Cited
2000
CpG islands frequently contain gene promoters or exons and are usually unmethylated in normal cells. Methylation of CpG islands… (More)
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… (More)
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Highly Cited
1996
Highly Cited
1996
Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes… (More)
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Highly Cited
1995
Highly Cited
1995
Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of… (More)
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