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CpG Islands

Known as: CpG island, CpG-Rich Islands, CpG-Rich Island 
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (1)

Base Sequence
Chromosomesaspects of radiation effectscytidylyl-3'-5'-guanosinephysiological aspects

Papers overview

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Highly Cited
2011
Highly Cited
2011
Hypomethylation of Intragenic LINE-1 Represses Transcription in Cancer Cells through AGO2
In human cancers, the methylation of long interspersed nuclear element -1 (LINE-1 or L1) retrotransposons is reduced. This occurs… 
Highly Cited
2005
Highly Cited
2005
CpG Oligodeoxynucleotides Adsorbed onto Polylactide-Co-Glycolide Microparticles Improve the Immunogenicity and Protective Activity of the Licensed Anthrax Vaccine
ABSTRACT To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This… 
Highly Cited
2003
Highly Cited
2003
Local Delivery of CpG Oligodeoxynucleotides Induces Rapid Changes in the Genital Mucosa and Inhibits Replication, but Not Entry, of Herpes Simplex Virus Type 2
ABSTRACT Mucosal surfaces are the entry sites for the vast majority of infectious pathogens and provide the first line of defense… 
Highly Cited
2002
Highly Cited
2002
Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo
Bacterial DNA and oligonucleotides (ODN) containing CpG‐motifs strongly activate cells of the immune system. Accordingly CpG‐DNA… 
Highly Cited
2001
Highly Cited
2001
Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma.
To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA… 
Highly Cited
2001
Highly Cited
2001
CpG ODN can re-direct the Th bias of established Th2 immune responses in adult and young mice.
Induction of an appropriate immune response is essential for successful immunization. For example, Th1 type immune responses are… 
Highly Cited
2000
Highly Cited
2000
Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants.
Highly Cited
1999
Highly Cited
1999
Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis.
Bacterial DNA and the synthetic CpG-oligodeoxynucleotides (ODNs) derived thereof have attracted attention because they activate… 
Highly Cited
1994
Highly Cited
1994
Germline mutations in the neurofibromatosis type 2 tumour suppressor gene.
The recent identification of the NF2 tumour suppressor gene has enabled large scale screening for pathological mutations in the… 
Review
1992
Review
1992
Methylation, mutation and cancer
The fifth base in human DNA, 5‐methylcytosine, is inherently mutagenic. This has led to marked changes in the distribution of the… 
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