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CpG Islands

Known as: CpG island, CpG-Rich Islands, CpG-Rich Island 
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several… Expand
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by… Expand
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Highly Cited
2009
Highly Cited
2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… Expand
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Highly Cited
2006
Highly Cited
2006
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing… Expand
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Highly Cited
2002
Highly Cited
2002
CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their genomes. In addition, CpG islands… Expand
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Highly Cited
2000
Highly Cited
2000
DNA from bacteria has stimulatory effects on mammalian immune cells, which depend on the presence of unmethylated CpG… Expand
Highly Cited
1999
Highly Cited
1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… Expand
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Highly Cited
1996
Highly Cited
1996
Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes… Expand
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Highly Cited
1995
Highly Cited
1995
Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of… Expand
Highly Cited
1993
Highly Cited
1993
Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study… Expand
Highly Cited
1987
Highly Cited
1987
Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been shown that some vertebrate genes… Expand