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Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by… Expand For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… Expand Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing… Expand CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their genomes. In addition, CpG islands… Expand DNA from bacteria has stimulatory effects on mammalian immune cells, which depend on the presence of unmethylated CpG… Expand Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… Expand Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes… Expand Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of… Expand Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study… Expand Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been shown that some vertebrate genes… Expand