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Complement component C4

Known as: Component, C4 Complement, Complement Component, C4, Complement Component-4 
Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length… 
National Institutes of Health

Related topics

Related topics

23 relations
Body FluidsC4A geneCD18 AntigensComplement Activation

Narrower (3)

C4 protein, mousecomplement C4A7complement C4d

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Macrophage-Derived Complement Component C4 Can Restore Humoral Immunity in C4-Deficient Mice1
Mice with a disrupted C4 locus (C4−/−) have an impaired immune response to thymus-dependent Ags. To test the role of bone marrow… 
Review
1990
Review
1990
Polymorphism of the human complement component C4.
The genes encoding the two C4 isotypes, C4A and C4B, lie 10 kb apart in the class III region of the human major… 
1990
1990
The complement component C4 of mammals.
Human complement component C4 is coded by tandem genes located in the HLA class III region. The products of the two genes, C4A… 
Highly Cited
1990
Highly Cited
1990
Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus
The two genes for the C4A and C4B isotypes of the fourth component of human complement are located in the MHC class III region… 
Highly Cited
1989
Highly Cited
1989
DNA methylation and the differential expression of C4 photosynthesis genes in mesophyll and bundle sheath cells of greening maize leaves.
Highly Cited
1983
Highly Cited
1983
Cloning of a human complement component C4 gene.
Six overlapping cosmid clones having an average insert size of 40 kilobase pairs were identified and isolated from a human… 
Highly Cited
1982
Highly Cited
1982
A molecular basis for the two locus model of human complement component C4
The major histocompatibility complex (MHC)-linked fourth component of complement (C4) shows a high degree of polymorphism in… 
Highly Cited
1979
Highly Cited
1979
Genetic polymorphism of human complement C4 and detection of heterozygotes
Many components of complement exhibit inherited structural polymorphism, with at least two alleles being common in one or more of… 
Highly Cited
1977
Highly Cited
1977
Regulation of C4 photosynthesis: characterization of a protein factor mediating the activation and inactivation of NADP-malate dehydrogenase.
Highly Cited
1966
Highly Cited
1966
Persistent Infection of a Rat Kidney Cell Line with Rauscher Murine Leukemia Virus
Duc-Nguyen, Huu (National Cancer Institute, Bethesda, Md.), Edith N. Rosenblum, and Robert F. Zeigel. Persistent infection of a… 
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