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complement C4d

Known as: complement 4d, C4d, complement component 4d fragment 
C4d (380 aa, ~41 kDa) is a fragment of complement component-4. This protein plays a role in the regulation of the classical and lectin complement… 
National Institutes of Health

Related topics

Related topics

13 relations
C4d Ag:PrThr:Pt:Tiss:Ord:Immune stainComplement ActivationComplement C4d measurementComplement C4d:EntNum:Pt:RBC:Qn

Broader (3)

Complement C4bComplement component C4Peptide Fragments

Papers overview

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Review
2011
Review
2011
C4d-negative antibody-mediated rejection in renal allografts: evidence for its existence and effect on graft survival.
The use of C4d staining as a tissue marker for humoral immunity has served an important role in allowing pathologists to more… 
Highly Cited
2007
Highly Cited
2007
Value of Posttransplant Antibody Tests in the Evaluation of Patients with Renal Graft Dysfunction
Posttransplant HLA antibodies correlate with C4d positive rejection and decreased graft survival. However, the diagnostic value… 
Highly Cited
2007
Highly Cited
2007
In Vitro Detection of C4d‐Fixing HLA Alloantibodies: Associations With Capillary C4d Deposition in Kidney Allografts
Capillary C4d deposition is a valuable marker of antibody‐mediated rejection (AMR). In this analysis, flow cytometric detection… 
Highly Cited
2007
Highly Cited
2007
C4d immunopositivity is uncommon in ABO‐compatible liver allografts, but correlates partially with lymphocytotoxic antibody status
Aims:  To determine whether C4d immunopositivity helps recognition of humoral rejection in dysfunctional liver allografts. 
Highly Cited
2006
Highly Cited
2006
Pivotal Role of Complement‐Fixing HLA Alloantibodies in Presensitized Kidney Allograft Recipients
Recipient presensitization represents a major risk factor for kidney allograft loss. Complement fixation may be a critical… 
Review
2003
Review
2003
Complement C4d in Graft Capillaries – the Missing Link in the Recognition of Humoral Alloreactivity
Staining of C4d in graft capillaries has emerged as a useful method to detect antibody‐mediated rejections in situ. Demonstration… 
Review
2002
Review
2002
C4d and the fate of organ allografts.
Research over the past ten years has revealed that humoral rejection of organ transplants is associated with C4d deposits along… 
Highly Cited
2002
Highly Cited
2002
C4d staining of perioperative renal transplant biopsies.
BACKGROUND Deposition of C4d in peritubular capillaries (PTCs) has been shown to be a sensitive marker for antibody-mediated… 
Highly Cited
2001
Highly Cited
2001
C4d-positive acute humoral renal allograft rejection: effective treatment by immunoadsorption.
There is increasing evidence for an important pathogenetic role of alloantibodies in acute renal allograft rejection. Acute… 
Highly Cited
1986
Highly Cited
1986
Impaired humoral immune response in complement C3‐deficient guinea pigs: absence of secondary antibody response
A recently described egenetically controlled C3 deficiency (C3D) in guinea pigs (GP) provided a unique model for studying the… 
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