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C4A gene

Known as: C4A2, C4S, C4A3 
This gene plays a role in the progression of the classical complement pathway.
National Institutes of Health

Related topics

Related topics

7 relations
C4A wt AlleleC4B geneC4B wt AlleleComplement Activation

Papers overview

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1995
1995
Familial anticardiolipin antibodies and C4 deficiency genotypes that coexist with MHC DQB1 risk factors.
OBJECTIVE To investigate the familial basis of antiphospholipid antibodies by studying putative risk factors at the C4 and MHC… 
Highly Cited
1993
Highly Cited
1993
Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression.
The fourth component of the human complement system (C4) is coded for by two genes, C4A and C4B, located within the MHC. Null… 
1993
1993
Covalent binding properties of the human complement protein C4 and hydrolysis rate of the internal thioester upon activation
The complement proteins C3 and C4 have an internal thioester. Upon activation on the surface of a target cell, the thioester… 
1992
1992
Structural differences between the two human complement C4 isotypes affect the humoral immune response
An animal model has been used to address the question of the biological importance of the known structural difference between the… 
Highly Cited
1990
Highly Cited
1990
Nucleotide sequence of the gene coding for four subunits of cytochrome c oxidase from the thermophilic bacterium PS3.
The gene coding for four subunits of cytochrome aa3-type oxidase was isolated from a genomic DNA library of the thermophilic… 
1990
1990
Homozygous C4A deficiency in systemic lupus erythematosus: analysis of patients from a defined population
Homozygous C4A deficiency was found at a prevalence of 16% (13/80 patients) in systemic lupus erythematosus (SLE). The patients… 
Highly Cited
1989
Highly Cited
1989
Association of homozygous C4B deficiency with bacterial meningitis.
The fourth component of complement (C4) is encoded by two separate but linked loci (C4A and C4B), each of which produces… 
Highly Cited
1987
Highly Cited
1987
Differential requirements for the processing and presentation of soluble and particulate bacterial antigens by macrophages
The requirements for antigen processing and presentation by macrophages using various forms of antigens derived from Listeria… 
1984
1984
C4 Polymorphism: Use of a Monoclonal Antibody to Distinguish C4A and C4B Locus Products
Abstract. A monoclonal antibody reactive against C4B locus products was used in a passive immunoblotting technique to distinguish… 
1983
1983
Glycosaminoglycan alterations in rat bone due to growth and fluorosis.
Evidence in the literature has suggested that alterations in bone glycosaminoglycans (GAGs) are at least partially responsible… 
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