Skip to search formSkip to main contentSkip to account menu

C4A gene

Known as: C4A2, C4S, C4A3 
This gene plays a role in the progression of the classical complement pathway.
National Institutes of Health

Related topics

Related topics

7 relations
C4A wt AlleleC4B geneC4B wt AlleleComplement Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Active immunization of hamsters against Clostridium difficile infection using surface-layer protein.
Clostridium difficile is the leading cause of infectious antibiotic-associated diarrhoea, particularly among the elderly. Its… 
Highly Cited
2003
Highly Cited
2003
Association between scanning laser polarimetry measurements using variable corneal polarization compensation and visual field sensitivity in glaucomatous eyes.
OBJECTIVE To compare the association between scanning laser polarimetry (SLP) retinal nerve fiber layer (RNFL) measurements and… 
Highly Cited
1993
Highly Cited
1993
Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression.
The fourth component of the human complement system (C4) is coded for by two genes, C4A and C4B, located within the MHC. Null… 
Highly Cited
1990
Highly Cited
1990
Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.
The C4B isotype of the fourth component of human complement (C4) displays 3- to 4-fold greater hemolytic activity than does its… 
Highly Cited
1990
Highly Cited
1990
Nucleotide sequence of the gene coding for four subunits of cytochrome c oxidase from the thermophilic bacterium PS3.
The gene coding for four subunits of cytochrome aa3-type oxidase was isolated from a genomic DNA library of the thermophilic… 
Highly Cited
1990
Highly Cited
1990
Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus
The two genes for the C4A and C4B isotypes of the fourth component of human complement are located in the MHC class III region… 
Highly Cited
1989
Highly Cited
1989
Association of homozygous C4B deficiency with bacterial meningitis.
The fourth component of complement (C4) is encoded by two separate but linked loci (C4A and C4B), each of which produces… 
Highly Cited
1986
Highly Cited
1986
Covalent binding properties of the C4A and C4B isotypes of the fourth component of human complement on several C1-bearing cell surfaces.
In a previous study we demonstrated that the thioester-mediated transacylation of the human C4B isotype onto sheep erythrocytes… 
Highly Cited
1982
Highly Cited
1982
A molecular basis for the two locus model of human complement component C4
The major histocompatibility complex (MHC)-linked fourth component of complement (C4) shows a high degree of polymorphism in… 
Highly Cited
1982
Highly Cited
1982
Elimination of specific DNA sequences from the somatic nucleus of the ciliate Tetrahymena
Tetrahymena micronuclear DNA fragments have been cloned in the plasmid pBR322. One clone, pTt 2512, has been found to contain the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)