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The pathophysiology and treatment of glaucoma: a review.
Primary care physicians can play an important role in the diagnosis of glaucoma by referring patients with positive family history or with suspicious optic nerve head findings for complete ophthalmologic examination and can improve treatment outcomes by reinforcing the importance of medication adherence and persistence. Expand
Primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is the most common type and management of POAG includes topical drug therapies and surgery to reduce IOP, although new therapies targeting neuroprotection of RGCs and axonal regeneration are under development. Expand
Evaluation of the Influence of Corneal Biomechanical Properties on Intraocular Pressure Measurements Using the Ocular Response Analyzer
ORA IOPCC measurements seem to provide an estimate of IOP that is less influenced by corneal properties than those provided by GAT, and these measurements were not associated with any of the ocular variables. Expand
Prevalence of Ocular Surface Disease in Glaucoma Patients
The coexistence of OSD and the use of BAK-containing medications may impact vision-related quality of life in this patient population of glaucoma patients. Expand
Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness.
- R. Weinreb, A. Dreher, A. Coleman, H. Quigley, B. Shaw, K. Reiter
- Materials Science, Medicine
- Archives of ophthalmology
- 1 April 1990
Quantitating retinal nerve fiber layer thickness may enhance discrimination between glaucomatous and normal eyes earlier than is currently available by anatomic and functional approaches. Expand
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
Although the diagnostic performance and the strength of the structure-function association were comparable between Cirrus HD-OCT and Stratus OCT RNFL measurements, Cirrus' measurement variability demonstrated lower measurement variability compared withstratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock. Expand
Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography.
- F. Medeiros, L. Zangwill, C. Bowd, R. Vessani, R. Susanna, R. Weinreb
- American journal of ophthalmology
RNFL and ONH measurements had the best discriminating performance among the several Stratus OCT parameters and improved the diagnostic accuracy for glaucoma detection using this instrument. Expand
Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes.
- John H. K. Liu, Xiaoyan Zhang, D. Kripke, R. Weinreb
- Investigative ophthalmology & visual science
- 1 April 2003
The diurnal IOP is higher, the diurnal-to-nocturnal change of habitual Iop is less, and the posture-independent IOP pattern around normal awakening time is different in eyes with early glaucomatous changes. Expand
Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma.
The abilities of current commercially available versions of 3 optical imaging techniques: scanning laser polarimetry with variable corneal compensation, confocal scanning laser ophthalmoscopy, and optical coherence tomography to discriminate between healthy eyes and eyes with glaucomatous visual field loss are compared. Expand
Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma
- Y. Yücel, Qiang Zhang, R. Weinreb, P. Kaufman, N. Gupta
- Progress in Retinal and Eye Research
- 1 July 2003
In an experimental primate model of unilateral glaucoma, degenerative changes are observed in magnocellular, parvo cellular, and koniocellular pathways in the lateral geniculate nucleus, and these changes are presented in relation to intraocular pressure and the severity of optic nerve damage. Expand