Complement-Dependent Cytotoxicity

Activated by cell-surface bound antibody, by immune complexes, or by microbial membrane carbohydrate, Complement-Dependent Cytotoxicity involves… (More)
National Institutes of Health

Papers overview

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2014
2014
Mortalin/GRP75, the mitochondrial heat shock protein 70, plays a role in cell protection from complement-dependent cytotoxicity… (More)
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2013
2013
The antitumor activity of monoclonal antibodies in the treatment of chronic lymphocytic leukemia is mediated mainly by antibody… (More)
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2012
2012
Nucleated cells are equipped with several mechanisms that support their resistance to complement-dependent cytotoxicity (CDC… (More)
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2012
2012
The presence or absence of core fucose in the Fc region N-linked glycans of antibodies affects their binding affinity toward Fc… (More)
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2010
2010
Mortalin, the mitochondrial hsp70, is a vital constitutively expressed heat shock protein. Its elevated expression has been… (More)
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2007
2007
CD46 is one of the complement-regulatory proteins expressed on the surface of normal and tumor cells for protection against… (More)
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2005
2005
One of several effector mechanisms thought to contribute to Ab efficacy against cancer is complement-dependent cytotoxicity (CDC… (More)
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Highly Cited
2001
Highly Cited
2001
This manuscript describes two sites in a human IgG1 that, when mutated individually or in combination, result in a dramatic… (More)
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Highly Cited
2001
Highly Cited
2001
We have shown previously that the anti-CD20 chimaeric monoclonal antibody rituximab exerts its effects on neoplastic B-lymphoma… (More)
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1987
1987
Mouse monoclonal antibody 2H7 recognizes the CD20 cell surface phosphoprotein that is expressed in normal as well as malignant B… (More)
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