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Complement C5a

Known as: Complement 5a, Complement Component 5a, Component 5a, Complement 
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal… 
National Institutes of Health

Related topics

Related topics

13 relations
C5 geneC5AR1 geneComplement C5a measurementComplement C5a:MCnc:Pt:Plas:Qn

Narrower (1)

C5aRAD

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Differential Regulation of Responsiveness to fMLP and C5a Upon Dendritic Cell Maturation: Correlation with Receptor Expression1 2
The trafficking of immature and mature dendritic cells (DCs) to different anatomical sites in vivo is critical for fulfilling… 
Highly Cited
1993
Highly Cited
1993
Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor.
Results obtained indicate that a site-directed polyclonal antibody specific for a synthetic peptide based on the predicted amino… 
1992
1992
C5a reduces formyl peptide-induced actin polymerization and phosphatidylinositol(3,4,5)trisphosphate formation, but not phosphatidylinositol (4,5) bisphosphate hydrolysis and superoxide production…
We investigated phospholipid signal transduction, calcium flux, O2- anion production and actin polymerization after stimulation… 
Highly Cited
1990
Highly Cited
1990
Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.
The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated… 
Highly Cited
1986
Highly Cited
1986
Lipopolysaccharide modulates receptors for leukotriene B4, C5a, and formyl-methionyl-leucyl-phenylalanine on rabbit polymorphonuclear leukocytes.
Peripheral blood polymorphonuclear leukocytes (PMNL) isolated from rabbits after an i.v. injection of endotoxin exhibited… 
Highly Cited
1985
Highly Cited
1985
Studies of human C5a as a mediator of inflammation in normal human skin.
C5a is an 11,000-D fragment of the fifth component of complement (C5) with potent anaphylatoxic and leukocyte chemotactic… 
Highly Cited
1985
Highly Cited
1985
Human C5a modulates monocyte Fc and C3 receptor expression.
FcIgG and C3 (CR1 and CR3) receptors are responsible for binding opsonized particles, phagocytosis, and immune adherence… 
Highly Cited
1983
Highly Cited
1983
Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a
The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP… 
Highly Cited
1981
Highly Cited
1981
Selective desensitization of neutrophils: further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues.
Human polymorphonuclear neutrophils aggregate and degranulate in response to 2 recently described platelet-activating… 
Highly Cited
1977
Highly Cited
1977
Mechanism of histamine release by formyl methionine-containing peptides.
Small, acylated, methionine-containing peptides release histamine from human basophils. The characteristics of this reaction were… 
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