Complement C5a

Known as: Complement 5a, Complement Component 5a, Component 5a, Complement 
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Costimulatory signals are critical to T cell activation, but how their effects are mediated remains incompletely characterized… (More)
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Highly Cited
2008
Highly Cited
2008
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally… (More)
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Highly Cited
2006
Highly Cited
2006
Immune mechanisms have been implicated in placental dysfunction in patients with recurrent miscarriages and intrauterine growth… (More)
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Highly Cited
2005
Highly Cited
2005
C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear… (More)
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Highly Cited
2003
Highly Cited
2003
C3a and C5a anaphylatoxins are cytokine-like polypeptides generated during complement (C) system activation and released at the… (More)
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Highly Cited
2002
Highly Cited
2002
The substantial variations in the responses of cells to the anaphylatoxin C5a and its desarginated form, C5adR(74), suggest that… (More)
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Highly Cited
2002
Highly Cited
2002
In leukocytes, C3a and C5a cause chemotaxis in a G(i)-dependent, pertussis toxin (PT)-sensitive fashion. Because we found that… (More)
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Highly Cited
1999
Highly Cited
1999
Activation of the human complement system of plasma proteins during immunological host defense can result in overproduction of… (More)
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Highly Cited
1994
Highly Cited
1994
Human umbilical vein endothelial cells have recently been shown to respond to C5a with increases in intracellular Ca2… (More)
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Highly Cited
1994
Highly Cited
1994
The complement peptides C3a and C5a have been shown previously to release histamine from human basophils but not human lung mast… (More)
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