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Complement C5a

Known as: Complement 5a, Complement Component 5a, Component 5a, Complement 
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal… 
National Institutes of Health

Related topics

Related topics

13 relations
C5 geneC5AR1 geneComplement C5a measurementComplement C5a:MCnc:Pt:Plas:Qn

Narrower (1)

C5aRAD

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes.
IL-12 is a key mediator of the immune response, skewing T lymphocytes toward a type 1 cytokine pattern. Priming with IFN-gamma or… 
Highly Cited
1993
Highly Cited
1993
Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor.
Results obtained indicate that a site-directed polyclonal antibody specific for a synthetic peptide based on the predicted amino… 
Highly Cited
1990
Highly Cited
1990
Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself.
We investigated the effects of recombinant C5a (rC5a) on gene expression and synthesis of interleukin-1 beta (IL-1 beta) and… 
Highly Cited
1990
Highly Cited
1990
Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.
The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated… 
Highly Cited
1990
Highly Cited
1990
Regulation of C5a and formyl peptide receptor expression on human polymorphonuclear leukocytes.
Fluorescein conjugates of C5a (FL-C5a) and formyl methionine-leucine-phenylalanine-lysine (FL-FMLPL) have been used to determine… 
Highly Cited
1985
Highly Cited
1985
Characterization of a C5a receptor on human polymorphonuclear leukocytes (PMN).
Elucidation of the interactions between C5a and granulocytes is central to understanding the role of C5a in inflammation. In this… 
Highly Cited
1983
Highly Cited
1983
Juvenile Periodontitis as a Model for Neutrophil Function: Reduced Binding of the Complement Chemotactic Fragment, C5a
The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP… 
Highly Cited
1979
Highly Cited
1979
Induction of lysosomal enzyme secretion by alveolar macrophages in response to the purified complement fragments C5a and C5a des-arg.
Purified C5a and its "inactive" form, C5a des-arg, were shown to induce secretion of acid hydrolases from rabbit alveolar… 
Highly Cited
1977
Highly Cited
1977
Mechanism of histamine release by formyl methionine-containing peptides.
Small, acylated, methionine-containing peptides release histamine from human basophils. The characteristics of this reaction were… 
Highly Cited
1976
Highly Cited
1976
Partial characterization of human C5a anaphylatoxin. I. Chemical description of the carbohydrate and polypeptide prtions of human C5a.
Human C5a was isolated from complement-activated serum and was characterized for protein and carbohydrate content. The purified… 
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