C5 gene

Known as: C5a anaphylatoxin, C5b, prepro-C5 
Human C5 wild-type allele is located within 9q33-q34 and is approximately 98 kb in length. This allele, which encodes complement C5 protein, is… (More)
National Institutes of Health

Papers overview

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2012
2012
The complement membrane attack complex (MAC) is formed by the sequential assembly of C5b with four homologous proteins as follows… (More)
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2008
2008
To provide insight into the structural and functional properties of human complement component 5 (C5), we determined its crystal… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting approximately 1% of the population. The disease… (More)
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Highly Cited
2006
Highly Cited
2006
Complement-mediated tissue injury in humans occurs upon deposition of immune complexes, such as in autoimmune diseases and acute… (More)
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2005
2005
AIMS Complement activation occurs in atherosclerotic lesions, and particularly complement component C5a exerts potent chemotactic… (More)
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1991
1991
Specific proteolytic destruction of the human chemotaxin, C5a, is a property of group A and B streptococcal pathogens. Here we… (More)
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Highly Cited
1991
Highly Cited
1991
HOST defence and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by a chemotactic… (More)
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1987
1987
The authors conducted a study in humans to determine the mediators associated with acute pulmonary vaso- and broncho-constriction… (More)
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1985
1985
We examined responses of human peripheral blood polymorphonuclear leukocytes (PMN) and monocytes to the highly purified human… (More)
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