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C5 gene

Known as: C5a anaphylatoxin, C5b, prepro-C5 
Human C5 wild-type allele is located within 9q33-q34 and is approximately 98 kb in length. This allele, which encodes complement C5 protein, is… 
National Institutes of Health

Related topics

Related topics

10 relations
C5AR1 geneC5a Anaphylatoxin, humanChemotaxisComplement Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Targeting complement component 5a promotes vascular integrity and limits airway remodeling
Increased microvascular dilatation and permeability is observed during allograft rejection. Because vascular integrity is an… 
1995
1995
Conversion of murine Fabs isolated from a combinatorial phage display library to full length immunoglobulins.
1995
1995
Decapeptide agonists of human C5a: the relationship between conformation and neutrophil response.
A series of decapeptide analogues corresponding to the C-terminal region of the human C5a anaphylatoxin (C5a65-74) was… 
Highly Cited
1989
Highly Cited
1989
Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.
Complement C6 is one of five plasma proteins that are incorporated into the lytic terminal complement complex on lipid membranes… 
Highly Cited
1989
Highly Cited
1989
Complement levels in septic primates treated with anti-C5a antibodies.
1981
1981
The conversion of human complement component C5 into fragment C5b by the alternative-pathway C5 convertase.
The cleavage of human complement component C5 to fragment C5b by the alternative pathway C5 convertase was studied. The… 
Highly Cited
1980
Highly Cited
1980
Biologial effects of the human complement fragments C5a and C5ades Arg on neutrophil function.
1980
1980
Neutrophil chemotaxis in response to surface-bound C5A.
Highly Cited
1976
Highly Cited
1976
Partial characterization of human C5a anaphylatoxin. I. Chemical description of the carbohydrate and polypeptide prtions of human C5a.
Human C5a was isolated from complement-activated serum and was characterized for protein and carbohydrate content. The purified… 
Highly Cited
1975
Highly Cited
1975
On the mechanism of cytolysis by complement: evidence on insertion of C5b and C7 subunits of the C5b,6,7 complex into phospholipid bilayers of erythrocyte membranes.
The doughnut hypothesis of cytolysis by complement [Mayer, M. M. (1972) Proc. Nat. Acad. Sci. USA 69, 2954-2958] describes an… 
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