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  • Xin Chen, Monika Bäumel, Daniela N Männel, O. M. Zack Howard, Joost J Oppenheim
  • Medicine, Biology
  • The Journal of Immunology
  • 2007 (First Publication: 1 July 2007)
  • Although TNF is a major proinflammatory cytokine, increasing evidence indicates that TNF also has immunosuppressive feedback effects. We have demonstrated in this study that, in both resting andExpand
  • Xin Chen, Jeffrey J. Subleski, Heather Kopf, O. M. Zack Howard, Daniela N Männel, Joost J Oppenheim
  • Biology, Medicine
  • The Journal of Immunology
  • 2008 (First Publication: 15 May 2008)
  • TNFR2 is predominantly expressed by a subset of human and mouse CD4+CD25+FoxP3+ T regulatory cells (Tregs). In this study, we characterized the phenotype and function of TNFR2+ Tregs in peripheralExpand
  • Xin Chen, Jeffrey J. Subleski, Ryoko Hamano, O. M. Zack Howard, Robert H. Wiltrout, Joost J Oppenheim
  • Biology, Medicine
  • European journal of immunology
  • 2010 (First Publication: 1 April 2010)
  • Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral blood (PB) FOXP3(+) cells present inExpand
  • Xin Chen, Lu Yang, +5 authors O. M. Zack Howard
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2003 (First Publication: 1 September 2003)
  • ABSTRACT Shikonin is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities, including inhibition ofExpand
  • Xin Chen, Joost J Oppenheim, Robin T. Winkler-Pickett, John R. Ortaldo, O. M. Zack Howard
  • Medicine, Biology
  • European journal of immunology
  • 2006 (First Publication: 1 August 2006)
  • IL-2 is crucial for the production of CD4(+)CD25(+) T regulatory (Treg) cells while important for the generation of effective T cell-mediated immunity. How to exploit the capacity of IL-2 to expandExpand
  • Annika M. Sääf, Jennifer M. Halbleib, +4 authors Patrick O. Brown
  • Biology, Medicine
  • Molecular biology of the cell
  • 2007 (First Publication: 15 August 2007)
  • Posttranslational mechanisms are implicated in the development of epithelial cell polarity, but little is known about the patterns of gene expression and transcriptional regulation during thisExpand