Skip to search formSkip to main contentSkip to account menu

Complement C5 Convertase, Classical Pathway

Known as: Classical Pathway C5 Convertase, Complement C5 Convertase, Classical Pathway [Chemical/Ingredient], C5 Convertase (C4b2a3b) 
A serine protease that cleaves multiple COMPLEMENT 5 into COMPLEMENT 5A (anaphylatoxin) and COMPLEMENT 5B in the CLASSICAL COMPLEMENT ACTIVATION… 
National Institutes of Health

Related topics

Related topics

8 relations
CDK5RAP1 geneProcess of secretionantagonists & inhibitorsaspects of radiation effects

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement.
2007
2007
Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase.
Highly Cited
2000
Highly Cited
2000
Functional Role of the Noncatalytic Subunit of Complement C5 Convertase1
The C5 convertase is a serine protease that consists of two subunits: a catalytic subunit which is bound in a Mg2+-dependent… 
1995
1995
Evidence for the involvement of arginine 462 and the flanking sequence of human C4 beta-chain in mediating C5 binding to the C4b subcomponent of the classical complement pathway C5 convertase.
Replacement of human C4 beta-chain residue arginine 458 by tryptophan, a substitution that occurs naturally in the hemolytically… 
1991
1991
Reconstitution of C5 convertase of the alternative complement pathway with isolated C3b dimer and factors B and D.
C5 convertase of the alternative complement pathway is a trimolecular complex consisting of two molecules of C3b and one molecule… 
1991
1991
Preferential inactivation of the C5 convertase of the alternative complement pathway by factor I and membrane cofactor protein (MCP).
1991
1991
A covalent dimer of complement C4b serves as a subunit of a novel C5 convertase that involves no C3 derivatives.
A C intermediate, LAC14, was prepared from TNP-aminocaproyl liposomes sensitized with anti-TNP antibody (Ab) and purified human… 
1983
1983
Surface-dependent modulation by H of C5 cleavage by the cell-bound alternative pathway C5 convertase of human complement.
Regulation by H of formation of the C3 and C5 alternative pathway convertases of complement on cells is dependent on such… 
1981
1981
The conversion of human complement component C5 into fragment C5b by the alternative-pathway C5 convertase.
The cleavage of human complement component C5 to fragment C5b by the alternative pathway C5 convertase was studied. The… 
Highly Cited
1976
Highly Cited
1976
C3 requirements for formation of alternative pathway C5 convertase.
Although alternative pathway C3 and C5 convertases both have active proteolytic sites dependent on the same protein, Bb, the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)