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DREADD not the designer compound Designer receptors exclusively activated by designer drugs (DREADDs) constitute a powerful… Expand BACKGROUND
Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10… Expand OBJECTIVE
The goal of this 5-year naturalistic study of patients treated with clozapine was to examine the incidence of treatment… Expand Cognitive function is markedly impaired in most patients with schizophrenia. Antecedents of this impairment are evident in… Expand OBJECTIVE
Dopamine D2 receptor occupancy measurements provide a valid predictor of antipsychotic response, extrapyramidal side… Expand BACKGROUND
Clozapine is effective for resistant schizophrenia. After two sudden deaths in physically well young men soon after… Expand BACKGROUND
Clozapine is an atypical antipsychotic agent that is more effective than standard neuroleptic drugs in the treatment… Expand Positron emission tomography and selective radioligands were used to determine D1 and D2 dopamine receptor occupancy induced by… Expand DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors… Expand The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine… Expand