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Clozapine

Known as: Clozapinum, Clozapin, 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- 
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
DREADD not the designer compound Designer receptors exclusively activated by designer drugs (DREADDs) constitute a powerful… Expand
Highly Cited
2003
Highly Cited
2003
BACKGROUND Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE The goal of this 5-year naturalistic study of patients treated with clozapine was to examine the incidence of treatment… Expand
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Review
1999
Review
1999
Cognitive function is markedly impaired in most patients with schizophrenia. Antecedents of this impairment are evident in… Expand
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Highly Cited
1999
Highly Cited
1999
OBJECTIVE Dopamine D2 receptor occupancy measurements provide a valid predictor of antipsychotic response, extrapyramidal side… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND Clozapine is effective for resistant schizophrenia. After two sudden deaths in physically well young men soon after… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Clozapine is an atypical antipsychotic agent that is more effective than standard neuroleptic drugs in the treatment… Expand
Highly Cited
1992
Highly Cited
1992
Positron emission tomography and selective radioligands were used to determine D1 and D2 dopamine receptor occupancy induced by… Expand
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Highly Cited
1991
Highly Cited
1991
DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors… Expand
Highly Cited
1988
Highly Cited
1988
The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine… Expand
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