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Clozapine
Known as:
Clozapinum
, Clozapin
, 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
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A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays…
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National Institutes of Health
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Related topics
Related topics
40 relations
Adrenergic alpha-Antagonists [MoA]
Bipolar Disorder
CYP1A2 protein, human
Clozapine 100 MG Oral Tablet
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Broader (6)
Antipsychotic Agents
Benzodiazepine
Benzodiazepines
Carbamazepine
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Narrower (8)
Clozaril
JL 13 compound
JL 18
Leponex
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine
Juan L. Gomez
,
J. Bonaventura
,
+10 authors
M. Michaelides
Science
2017
Corpus ID: 29359705
DREADD not the designer compound Designer receptors exclusively activated by designer drugs (DREADDs) constitute a powerful…
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Review
2013
Review
2013
Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
S. Leucht
,
A. Cipriani
,
+12 authors
John M. Davis
The Lancet
2013
Corpus ID: 32085212
Highly Cited
2009
Highly Cited
2009
Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
S. Leucht
,
C. Corves
,
D. Arbter
,
R. Engel
,
Chunbo Li
,
John M. Davis
The Lancet
2009
Corpus ID: 1071537
Highly Cited
2003
Highly Cited
2003
Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).
H. Meltzer
,
L. Alphs
,
+85 authors
M. Zimmerman
Archives of General Psychiatry
2003
Corpus ID: 15444200
BACKGROUND Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10…
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Highly Cited
2000
Highly Cited
2000
Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic study.
D. Henderson
,
E. Cagliero
,
+4 authors
D. Goff
American Journal of Psychiatry
2000
Corpus ID: 8461635
OBJECTIVE The goal of this 5-year naturalistic study of patients treated with clozapine was to examine the incidence of treatment…
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Review
1999
Review
1999
The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia.
H. Meltzer
,
S. McGurk
Schizophrenia bulletin
1999
Corpus ID: 14242089
Cognitive function is markedly impaired in most patients with schizophrenia. Antecedents of this impairment are evident in…
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Highly Cited
1993
Highly Cited
1993
Clozapine-induced agranulocytosis. Incidence and risk factors in the United States.
J. Alvir
,
J. Lieberman
,
A. Safferman
,
J. Schwimmer
,
John A. Schaaf
New England Journal of Medicine
1993
Corpus ID: 22546329
BACKGROUND Clozapine is an atypical antipsychotic agent that is more effective than standard neuroleptic drugs in the treatment…
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Highly Cited
1992
Highly Cited
1992
Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.
L. Farde
,
A. Nordström
,
F. Wiesel
,
S. Pauli
,
C. Halldin
,
G. Sedvall
Archives of General Psychiatry
1992
Corpus ID: 16947464
Positron emission tomography and selective radioligands were used to determine D1 and D2 dopamine receptor occupancy induced by…
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Highly Cited
1991
Highly Cited
1991
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
H. V. Tol
,
J. Bunzow
,
+4 authors
O. Civelli
Nature
1991
Corpus ID: 4244670
DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors…
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Highly Cited
1988
Highly Cited
1988
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
J. Kane
,
G. Honigfeld
,
J. Singer
,
H. Meltzer
Archives of General Psychiatry
1988
Corpus ID: 20625485
The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine…
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