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Clozapine

Known as: Clozapinum, Clozapin, 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- 
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Summary Background Schizophrenia is one of the most common, burdensome, and costly psychiatric disorders in adults worldwide… Expand
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Review
2018
Review
2018
Clozapine is the most effective anti-psychotic medication for treatment refractory schizophrenia. A growing number of case… Expand
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Review
2018
Review
2018
Schizophrenia is the eighth leading cause of disability worldwide in people aged 15–44 years. Before antidopaminergic… Expand
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Review
2017
Review
2017
Clozapine is a highly effective antipsychotic medication, which provides a range of significant benefits for patients with… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE The goal of this 5-year naturalistic study of patients treated with clozapine was to examine the incidence of treatment… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Clozapine is an atypical antipsychotic agent that is more effective than standard neuroleptic drugs in the treatment… Expand
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Highly Cited
1992
Highly Cited
1992
Positron emission tomography and selective radioligands were used to determine D1 and D2 dopamine receptor occupancy induced by… Expand
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Highly Cited
1991
Highly Cited
1991
DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors… Expand
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Highly Cited
1988
Highly Cited
1988
The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine… Expand
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