Clozapine

Known as: Clozapinum, Clozapin, 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- 
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
OBJECTIVE When a schizophrenia patient has an inadequate response to treatment with an antipsychotic drug, it is unclear what… (More)
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Review
2005
Review
2005
Cognitive impairment is a core feature of schizophrenia and a major impediment to social and vocational rehabilitation. A number… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE The goal of this 5-year naturalistic study of patients treated with clozapine was to examine the incidence of treatment… (More)
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Highly Cited
2000
Highly Cited
2000
We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Clozapine is effective for resistant schizophrenia. After two sudden deaths in physically well young men soon after… (More)
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Highly Cited
1999
Highly Cited
1999
OBJECTIVE Dopamine D2 receptor occupancy measurements provide a valid predictor of antipsychotic response, extrapyramidal side… (More)
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Highly Cited
1992
Highly Cited
1992
Positron emission tomography and selective radioligands were used to determine D1 and D2 dopamine receptor occupancy induced by… (More)
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Highly Cited
1991
Highly Cited
1991
DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors… (More)
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Highly Cited
1988
Highly Cited
1988
The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine… (More)
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