Leponex

Clozapine was one of the major advances in the treatment of schizophrenia since the introduction of the classic antipsychotic… (More)

A 67 year-old woman in steady-state treatment with clozapine 150 mg/24 h was co-medicated with 100 mg/24 h of fluvoxamine. During… (More)

Ever since clozapine was discovered, researchers have been attempted to answer the question of what makes it different and how to… (More)

Leponex (clozapine) is an atypical neuroleptic indicated in severe schizophrenia, launched in France in December 1991. The safety… (More)

Granulocytopenia 1 is an established risk of treatment with tricyclic antipsychotic agents, including the phenothiazine group… (More)

Clozapin holds pharmacologically and clinically a special position among psychoactive drugs. By means of EEG examinations in 25… (More)

The authors studied a prolonged (3--5 years) use of leponex in 23 patients with the most progressive forms of schizophrenia… (More)

The levels of two endorphines, endogenously occurring morphinomimetic peptides, were measured in serial samples of CSF from seven… (More)

The clinical picture and the therapeutic management of a severe case of self-poisoning with Leponex (clozapin) are presented. In… (More)

Until now the "neuroleptic threshold" (Haase) was considered to be the efficiency criterion of the antipsychotic effect of a… (More)