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Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain
STUDIES on the pharmacology of the noradrenergic cyclic AMP-generating system in slices from the limbic forebrain of the rat1 and on adaptive properties of this system in conditions of persistentExpand
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Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant
Desipramine (DMI), a tricyclic antidepressant drug used in the treatment of depression, has been shown to increase steady-state levels of glucocorticoid receptor type II (GRII) mRNA in vitro and inExpand
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Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?
Summary. Chronic administration of noradrenergic antidepressants causes a desensitization of the beta adrenoceptor coupled adenylate cyclase system. In the present studies, we attempted to answer theExpand
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Human fibroblasts as a relevant model to study signal transduction in affective disorders.
BACKGROUND Previous studies have demonstrated a blunted beta adrenoceptor-linked protein kinase A (PKA) response in the 900xg supernatant fraction of human fibroblasts cultured from patients withExpand
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Imipramine and desmethylimipramine (DMI) in rats prevent and even reverse the sedative effects of reserpine and certain benzoquinolizines such as Ro 4-1284. The antisedative effects of theseExpand
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Antidepressant treatments and regulation of norepinephrine-receptor-coupled adenylate cyclase systems in brain.
  • F. Sulser
  • Chemistry, Medicine
  • Advances in biochemical psychopharmacology
  • 1984
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Mode of action of antidepressant drugs.
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Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms.
Earlier studies from our laboratory have demonstrated a marked reduction in the brain level of 5-hydroxytryptamine (5-HT) and in the activity of tryptophan hydroxylase which persists for severalExpand
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Regulation of recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: Implications for the therapy of depression
Abstract In this paper, the characteristics and the regulation of the norepinephrine (NE) receptor-coupled adenylate cyclase system with its β-adrenoceptor sub-population in brain are reviewed. WhileExpand
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The role of CREB and other transcription factors in the pharmacotherapy and etiology of depression
  • F. Sulser
  • Medicine
  • Annals of medicine
  • 1 January 2002
Psychiatric diseases are genetically complex and consequently, altered programs of gene expression have been hypothesized as the molecular basis of psychopathology. Since transcription factorsExpand
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