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Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain
STUDIES on the pharmacology of the noradrenergic cyclic AMP-generating system in slices from the limbic forebrain of the rat1 and on adaptive properties of this system in conditions of persistentExpand
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Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant
Desipramine (DMI), a tricyclic antidepressant drug used in the treatment of depression, has been shown to increase steady-state levels of glucocorticoid receptor type II (GRII) mRNA in vitro and inExpand
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Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?
Summary. Chronic administration of noradrenergic antidepressants causes a desensitization of the beta adrenoceptor coupled adenylate cyclase system. In the present studies, we attempted to answer theExpand
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Human fibroblasts as a relevant model to study signal transduction in affective disorders.
BACKGROUND Previous studies have demonstrated a blunted beta adrenoceptor-linked protein kinase A (PKA) response in the 900xg supernatant fraction of human fibroblasts cultured from patients withExpand
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SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).
Imipramine and desmethylimipramine (DMI) in rats prevent and even reverse the sedative effects of reserpine and certain benzoquinolizines such as Ro 4-1284. The antisedative effects of theseExpand
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Antidepressant treatments and regulation of norepinephrine-receptor-coupled adenylate cyclase systems in brain.
  • F. Sulser
  • Chemistry, Medicine
  • Advances in biochemical psychopharmacology
  • 1984
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Mode of action of antidepressant drugs.
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Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms.
Earlier studies from our laboratory have demonstrated a marked reduction in the brain level of 5-hydroxytryptamine (5-HT) and in the activity of tryptophan hydroxylase which persists for severalExpand
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Regulation of recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: Implications for the therapy of depression
Abstract In this paper, the characteristics and the regulation of the norepinephrine (NE) receptor-coupled adenylate cyclase system with its β-adrenoceptor sub-population in brain are reviewed. WhileExpand
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The role of CREB and other transcription factors in the pharmacotherapy and etiology of depression
  • F. Sulser
  • Medicine
  • Annals of medicine
  • 1 January 2002
Psychiatric diseases are genetically complex and consequently, altered programs of gene expression have been hypothesized as the molecular basis of psychopathology. Since transcription factorsExpand
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