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Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
TLDR
Treatment failure and CNS side-effects are associated with low and high efavirenz plasma levels, respectively, which strongly argues for dose adjustment on the basis of therapeutic drug monitoring to optimize treatment.
Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes.
TLDR
Voriconazole therapeutic drug monitoring improves the efficacy and safety of therapy in severely ill patients with invasive mycoses and aids in prompt and complete neurological recovery.
Interindividual Variability of the Clinical Pharmacokinetics of Methadone
TLDR
Because of the high morbidity and mortality associated with opioid dependence, it is of major importance that methadone is used at an effective dosage in maintenance treatment: at least 60 mg/day, but typically 80–100 mg/ day.
Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
TLDR
CYP2B6 genotyping may be useful to complement an individualization strategy based on plasma drug determinations to increase the safety and tolerability of EFV.
Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Temozolomide in Malignant Glioma Patients
TLDR
This is the first human pharmacokinetic study on TMZ to quantify CSF penetration and systemic or cerebral exposures are not better predictors than the cumulative dose alone for both efficacy and safety.
Towards a new combination therapy for tuberculosis with next generation benzothiazinones
TLDR
Compared to BTZ043, PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB), and when combined with other TB drugs, it showed additive activity against M. tuberculosis in vitro except with bedaquiline (BDQ) where synergy was observed.
Diet Acids and Alkalis Influence Calcium Retention in Bone
TLDR
It is confirmed that renally excreted acids derived from food influence calcium metabolism, and that alkalizing nutrients inhibit bone resorption, and further studies are needed to determine the clinical impact of dietary counseling for avoiding diet acids as a preventive measure against osteoporosis.
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib.
TLDR
Several pharmacokinetic aspects yet remain insufficiently investigated for imatinib mesylate, dasatinib, and nilotinib and widely prescribed co-medications, including known inhibitors or inducers of cytochrome P450 or drug transporters are reviewed.
Oral administration of a low dose of midazolam (75 μg) as an in vivo probe for CYP3A activity
TLDR
A low oral dose of midazolam can be used to measure the in vivo CYP3A activity, either by the determination of total 1′OH-midZolam/midazol am ratios at 30 min or by thedetermination of midAZolam plasma levels between 1.5 h and 4 h after its administration.
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