Clonal Anergy

Known as: Clonal Anergies, Anergy, Anergies, Clonal 
Diminished immune responsiveness to specific antigens. Induced or programmed clonal lymphocyte anergy is believed to be the second major mechanism… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
It has been shown that mesenchymal stem cells (MSCs) induce T cells to become unresponsive. We characterized the phenotype of… (More)
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Highly Cited
2005
Highly Cited
2005
Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs… (More)
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Highly Cited
2005
Highly Cited
2005
We studied the immunoregulatory features of murine mesenchymal stem cells (MSCs) in vitro and in vivo. MSCs inhibited T-cell… (More)
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Review
2003
Review
2003
T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen… (More)
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Highly Cited
1999
Highly Cited
1999
Costimulation (signal 2) has been proposed to inhibit the induction of T cell clonal anergy by either directly antagonizing… (More)
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Highly Cited
1998
Highly Cited
1998
The priming of tumor-antigen-specific T cells is critical for the initiation of successful anti-tumor immune responses, yet the… (More)
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Highly Cited
1993
Highly Cited
1993
The maximal T-cell response to its antigen requires presentation of the antigen by a major histocompatibility complex class II… (More)
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Highly Cited
1992
Highly Cited
1992
OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is… (More)
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Highly Cited
1992
Highly Cited
1992
Stimulation of a normal type I mouse T helper cell clone (TH1) with concanavalin A in the absence of antigen presenting cells… (More)
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Highly Cited
1990
Highly Cited
1990
During development in the thymus, T cells are rendered tolerant to self antigens. It is now apparent that thymocytes bearing self… (More)
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