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Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
We report the isolation of bcl-x, a bcl-2-related gene that can function as a bcl-2-independent regulator of programmed cell death (apoptosis). Alternative splicing results in two distinct bcl-xExpand
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Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening and lambda expression cloning identified a novel interacting protein,Expand
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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.
T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present dataExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.
Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces apoptosis in MM cells; however, the nature of its selectivity remainsExpand
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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repressExpand
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Bcl-XL and Bcl-2 repress a common pathway of cell death
The effect of Bcl-xL upon the developmental death of T cells was assessed by generating transgenic mice that expressed Bcl-xL within all thymocyte subsets. Bcl-xL protected thymocytes from a varietyExpand
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bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.
Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking functional bcl-2 exhibited normal development and maintenance of theExpand
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Regulation of Bcl-xL: a little bit of this and a little bit of STAT
The Bcl-2 family of proteins are key regulators of apoptosis. Bcl-xL is an anti-apoptotic protein with a high degree of homology to Bcl-2; however, the signals that regulate Bcl-xL and Bcl-2 appearExpand
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