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Clavulanic Acid

Known as: (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, ácido clavulánico, 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha)) 
A semisynthetic beta-lactamase inhibitor isolated from Streptomyces. Clavulanic acid contains a beta-lactam ring and binds strongly to beta-lactamase… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The overuse of antibiotics and the emergence of antibiotic-resistant bacterial strains is a global concern. This concern is also… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Researchers have suggested that antibiotics could cure acute appendicitis. We assessed the efficacy of amoxicillin… Expand
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Review
2006
Review
2006
The increasing trend of carbapenem resistance in Acinetobacter baumannii worldwide is a concern since it limits drastically the… Expand
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Highly Cited
2003
Highly Cited
2003
In this study, antioxidant and antimicrobial activities of water and ethanol extracts of anise (Pimpinella anisum L.) seed (PAS… Expand
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Review
2002
Review
2002
Carbapenemases may be defined as beta-lactamases that significantly hydrolyze at least imipenem or/and meropenem. Carbapenemases… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT A Klebsiella pneumoniae isolate showing moderate to high-level imipenem and meropenem resistance was investigated. The… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT Pseudomonas aeruginosa COL-1 was identified in a blood culture of a 39-year-old-woman treated with imipenem in… Expand
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Review
1995
Review
1995
A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are… Expand
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Highly Cited
1991
Highly Cited
1991
We isolated an imipenem-resistant strain, GN17203, of Pseudomonas aeruginosa. The strain produced a beta-lactamase that… Expand
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Highly Cited
1977
Highly Cited
1977
A novel β-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid… Expand
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