Skip to search formSkip to main contentSkip to account menu

Clavulanic Acid

Known as: (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, ácido clavulánico, 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha)) 
A semisynthetic beta-lactamase inhibitor isolated from Streptomyces. Clavulanic acid contains a beta-lactam ring and binds strongly to beta-lactamase… 
National Institutes of Health

Related topics

Related topics

15 relations
Amoxicillin 250 MG / Clavulanate 125 MG Oral Tablet [Augmentin]Amoxicillin 875 MG / Clavulanate 125 MG Oral TabletClavulanate / TicarcillinIn Blood

Narrower (4)

BRL-14151ClavulanateClavulanic Acid, Monosodium Saltclavulanate potassium

Broader (2)

Clavulanic Acidsbeta-Lactamase Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid
SummaryWe report the case of a patient with amoxicillinclavulanic acid-induced hepatitis with histologic multiple granulomas… 
2002
2002
Clavulanic Acid Degradation in Streptomyces clavuligerus Fed‐Batch Cultivations
Clavulanic acid (CA) is an important antibiotic that is produced by Streptomyces clavuligerus. CA is unstable and product… 
1986
1986
Bactericidal effects of ticarcillin-clavulanic acid against beta-lactamase-producing bacteria in vivo
The comparative efficacies of ticarcillin and ticarcillin plus clavulanic acid have been determined in the mouse against… 
1985
1985
Bactericidal effects of amoxycillin/clavulanic acid and ticarcillin/clavulanic acid in in-vitro kinetic models.
The bactericidal effects of amoxycillin and ticarcillin in the presence of clavulanic acid against beta-lactamase-producing… 
Highly Cited
1984
Highly Cited
1984
In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates
A total of 632 clinical bacterial isolates were tested for susceptibility to twofold dilutions of ticarcillin alone and in… 
1984
1984
Penicillanic acid sulfone: nature of irreversible inactivation of RTEM beta-lactamase from Escherichia coli.
When penicillanic acid sulfone in large molar excess is incubated with the RTEM beta-lactamase, the enzyme becomes inactivated… 
1983
1983
The penetration of amoxycillin/clavulanic acid into peritoneal fluid.
Thirty patients undergoing elective abdominal surgery were given 1 g amoxycillin plus 0 . 2 g clavulanic acid as a single… 
1982
1982
Activities of amoxicillin and clavulanic acid combinations against urinary tract infections
Urinary tract infection caused by beta-lactamase-producing bacteria were treated with 500 mg of amoxicillin three times daily… 
1981
1981
In vitro and in vivo synergism between amoxicillin and clavulanic acid against ampicillin-resistant Haemophilus influenzae type b
Eight strans of ampicillin-resistant beta-lactamase-producing Haemophilus influenzae type b were studied in vitro for synergy… 
1979
1979
An in vitro evaluation of clavulanic acid, a potent, broad-spectrum beta-lactamase inhibitor.
The in vitro efficacy of clavulanic acid, a new broad-spectrum inhibitor of enterobacterial beta-lactamases, was investigated. In…