Clavulanic Acid

Known as: (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, ácido clavulánico, 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha)) 
A semisynthetic beta-lactamase inhibitor isolated from Streptomyces. Clavulanic acid contains a beta-lactam ring and binds strongly to beta-lactamase… (More)
National Institutes of Health

Papers overview

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Review
2006
Review
2006
The increasing trend of carbapenem resistance in Acinetobacter baumannii worldwide is a concern since it limits drastically the… (More)
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Review
2005
Review
2005
Extended-spectrum beta-lactamases (ESBLs) are a rapidly evolving group of beta-lactamases which share the ability to hydrolyze… (More)
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Highly Cited
2005
Highly Cited
2005
Dennis L. Stevens, Alan L. Bisno, Henry F. Chambers, E. Dale Everett, Patchen Dellinger, Ellie J. C. Goldstein, Sherwood L… (More)
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Highly Cited
2001
Highly Cited
2001
A Klebsiella pneumoniae isolate showing moderate to high-level imipenem and meropenem resistance was investigated. The MICs of… (More)
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Highly Cited
1997
Highly Cited
1997
Clinical isolate Pseudomonas aeruginosa Mus showed resistance both to extended-spectrum cephalosporins and to aztreonam. We… (More)
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Review
1995
Review
1995
A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are… (More)
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1991
1991
This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of… (More)
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1990
1990
Clavulanic acid enhances the antibacterial spectrum of amoxicillin by rendering most β-lactamase-producing isolates susceptible… (More)
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1978
1978
Clavulanic acid, Z-(2R,5R)-3-(beta-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0] heptane-2-carboxylic acid, has been shown… (More)
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Highly Cited
1977
Highly Cited
1977
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid… (More)
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