• Publications
  • Influence
Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria.
  • K. Bush, J. Fisher
  • Biology, Medicine
    Annual review of microbiology
  • 22 September 2011
Most geographical regions now report KPC serine carbapenemases and the metallo-β-lactamases VIM, IMP, and NDM-1, even though N DM-1 was only recently identified.
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function
The identification of an allosteric binding domain—a remarkable 60 Å distant from the dd-transpeptidase active site—discovered by crystallographic analysis of a soluble construct of PBP2a opens an unprecedented realm for β-lactam antibiotic structure-based design.
Three-dimensional structure of the bacterial cell wall peptidoglycan.
The 3D solution structure as determined by NMR of the 2-kDa NAG-NAM(pentapeptide)-NAG-Nam(pentAPEptide) synthetic fragment of the cell wall is reported and a model for the bacterial cell wall has been proposed.
β-Lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome
Strains of S. aureus exhibiting either β-lactamase or PBP 2a-directed resistance (or both) have established a considerable ecological niche among human pathogens and ushered in a new and disconcerting chapter in the evolution of this organism.
Bacterial cell‐wall recycling
The involvement of peptidoglycan recycling with resistance regulation suggests that inhibitors of the enzymes involved in the recycling might synergize with cell‐wall–targeted antibiotics, and recent advances toward the discovery of cell‐ wall–recycling inhibitors are described.
Recent advances in MMP inhibitor design
This review summarizes the progression of chemical structure and mechanistic thinking toward these objectives, with emphasis on the disappointment, the perseverance, and the resilient optimism that such an inhibitor is there to be discovered.
Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.
Three-dimensional potential energy surfaces reveal the existence of two routes to the tetrahedral species and show that the previously proposed pathway, involving Glu166 as the general base promoting Ser70 through a conserved water molecule, exists in competition with the Lys73 process.
The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.
The seminal observations of the past decades are connected to new observations that resolve some, but certainly not all, of the key structures and mechanisms that connect to AmpR.