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Chromosomal structural abnormalities

Known as: Chromosomal Rearrangement, Structural Chromosome Aberration, Structural Chromosomal Abnormality 
Any change in the structure of one or more chromosomes.
National Institutes of Health

Related topics

Related topics

9 relations
Acute Myeloid Leukemia with Recurrent Genetic AbnormalitiesAcute Promyelocytic LeukemiaCore Binding Factor Acute Myeloid LeukemiaCytogenetically Normal Acute Myeloid Leukemia
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Centromere Repeats: Hidden Gems of the Genome
Satellite DNAs are now regarded as powerful and active contributors to genomic and chromosomal evolution. Paired with mobile… Expand
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Review
2018
Review
2018
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility… Expand
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Review
2018
Review
2018
Mutational game changer: Chromothripsis and its emerging relevance to cancer.
In recent years, the paradigm that genomic abnormalities in cancer cells arise through progressive accumulation of mutational… Expand
Review
2018
Review
2018
Genomic disorders 20 years on—mechanisms for clinical manifestations
Genomic disorders result from copy‐number variants (CNVs) or submicroscopic rearrangements of the genome rather than from single… Expand
Review
2017
Review
2017
Role of RUNX1 in hematological malignancies.
RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of… Expand
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Highly Cited
2013
Highly Cited
2013
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.
BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated… Expand
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Highly Cited
2011
Highly Cited
2011
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Summary Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to… Expand
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Highly Cited
2005
Highly Cited
2005
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to… Expand
Highly Cited
2005
Highly Cited
2005
Initial sequence of the chimpanzee genome and comparison with the human genome
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we… Expand
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Highly Cited
1996
Highly Cited
1996
AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis
The AML1-CBF beta transcription factor is the most frequent target of chromosomal rearrangements in human leukemia. To… Expand
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