Chromosomal structural abnormalities

RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of… Expand

Background Polyploidy or whole-genome duplication is now recognized as being present in almost all lineages of higher plants… Expand

Cancer is often driven by the accumulation of genetic alterations, including single nucleotide variants, small insertions or… Expand

BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated… Expand

Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex… Expand

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we… Expand

Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to… Expand

Several authors have proposed that speciation frequently occurs when a population becomes fixed for one or more chromosomal… Expand

The AML1-CBF beta transcription factor is the most frequent target of chromosomal rearrangements in human leukemia. To… Expand

We have developed epifluorescence filter sets and computer software for the detection and discrimination of 27 different DNA… Expand