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Power failure: why small sample size undermines the reliability of neuroscience
A study with low statistical power has a reduced chance of detecting a true effect, but it is less well appreciated that low power also reduces the likelihood that a statistically significant resultExpand
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Mouse genomic variation and its effect on phenotypes and gene regulation
We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of theExpand
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Missing heritability and strategies for finding the underlying causes of complex disease
Although recent genome-wide studies have provided valuable insights into the genetic basis of human disease, they have explained relatively little of the heritability of most complex traits, and theExpand
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A method for fine mapping quantitative trait loci in outbred animal stocks.
High-resolution mapping of quantitative trait loci (QTL) in animals has proved to be difficult because the large effect sizes detected in crosses between inbred strains are often caused by numerousExpand
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Sparse whole genome sequencing identifies two loci for major depressive disorder
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, noExpand
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Genome-wide genetic association of complex traits in heterogeneous stock mice
Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolutionExpand
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Subtle chromosomal rearrangements in children with unexplained mental retardation
BACKGROUND No explanation for moderate to severe mental retardation is apparent in about 40% of cases. Although small chromosomal rearrangements may account for some undiagnosed cases, a lack ofExpand
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A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. UsingExpand
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Strategies for mapping and cloning quantitative trait genes in rodents
Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1% have been characterized at a molecularExpand
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The population genetics of the haemoglobinopathies.
The haemoglobinopathies are the commonest single gene disorders known, and are so common in some regions of the world that the majority of the population carries at least one genetic abnormalityExpand
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