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Multicolor Spectral Karyotyping of Human Chromosomes
Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization, and all human chromosomes were simultaneously identified.
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
The human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin and contributes to the propagation of a specialized chromatin state at mammalian telomeres, which in turn is required for proper telomere metabolism and function.
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
It is demonstrated that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation.
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Positional stability of single double-strand breaks in mammalian cells
It is demonstrated that broken ends are positionally stable and unable to roam the cell nucleus, which supports a contact-first model in which chromosome translocations predominantly form among spatially proximal DSBs.
From Silencing to Gene Expression Real-Time Analysis in Single Cells
H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility
DPEP1 Inhibits Tumor Cell Invasiveness, Enhances Chemosensitivity and Predicts Clinical Outcome in Pancreatic Ductal Adenocarcinoma
Evidence is provided that DPEP1 plays a role in pancreatic cancer aggressiveness and predicts outcome in patients with resected PDAC and it is proposed thatDPEP1 may be a candidate target in PDAC for designing improved treatments.