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ABSTRACT To cause disease, Clostridium difficile spores must germinate in the host gastrointestinal tract. Germination is… Expand Carbonic anhydrase, a zinc enzyme found in organisms from all kingdoms, catalyses the reversible hydration of carbon dioxide and… Expand A series of 6alpha-alkyl-substituted analogues of chenodeoxycholic acid (CDCA) were synthesized and evaluated as potential… Expand Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly… Expand The major metabolic pathway for elimination of cholesterol is via conversion to bile acids. In addition to this metabolic… Expand The conversion of cholesterol into bile acids in the liver represents the major catabolic pathway for the removal of cholesterol… Expand We studied the effect of chenodeoxycholic acid in 17 patients with cerebrotendinous xanthomatosis. Before treatment, all subjects… Expand A double-masked study was conducted to determine the efficacy and safety of randomly allocated chenodiol (chenodeoxycholic acid… Expand RECEIVED for review February 21, 1978. Accepted June 19, 1978. NMR spectra since two distinct peaks (6 -3.38, 3.78 ppm) caused by… Expand Abstract Seven women with gallstones were given 0.75 to 4.5 g per day of chenodeoxycholic acid, a primary bile acid, to promote… Expand