Chenodeoxycholic Acid

Known as: Chenocholic acid, Chenodesoxycholic acid, Chenodiol 
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed… (More)
National Institutes of Health

Related topics

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32 relations

Narrower (16)

24-norchenodeoxycholic acid3,7-dihydroxy-12-oxocholanoic acid3,7-dihydroxycholane-24-sulfonateChenix
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Broader (4)

Bile Acids and SaltsCatharticsDeoxycholic AcidGastrointestinal Agents
Drug AllergyIn BloodLiver diseasesPancreatitis
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease.
BACKGROUND & AIMS Obeticholic acid (OCA; INT-747, 6α-ethyl-chenodeoxycholic acid) is a semisynthetic derivative of the primary… (More)
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Highly Cited
2010
Highly Cited
2010
Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid.
To cause disease, Clostridium difficile spores must germinate in the host gastrointestinal tract. Germination is initiated upon… (More)
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Highly Cited
2010
Highly Cited
2010
Dye-sensitized solar cells.
The effect of chemical modification of mesoporous TiO2 electrodes by 2-(4-butoxyphenyl)-N-hydroxyacetamide (BPHA) before dye… (More)
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Highly Cited
2002
Highly Cited
2002
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
A series of 6alpha-alkyl-substituted analogues of chenodeoxycholic acid (CDCA) were synthesized and evaluated as potential… (More)
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Highly Cited
2002
Highly Cited
2002
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
1999
Highly Cited
1999
Bile acids: natural ligands for an orphan nuclear receptor.
Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly… (More)
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Highly Cited
1999
Highly Cited
1999
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.
The major metabolic pathway for elimination of cholesterol is via conversion to bile acids. In addition to this metabolic… (More)
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Highly Cited
1993
Highly Cited
1993
Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers.
How lipophilic acids move across membranes, either model or biological, is the subject of controversy. We describe experiments… (More)
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Highly Cited
1989
Highly Cited
1989
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
The conversion of cholesterol into bile acids in the liver represents the major catabolic pathway for the removal of cholesterol… (More)
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Highly Cited
1984
Highly Cited
1984
Long-term treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid.
We studied the effect of chenodeoxycholic acid in 17 patients with cerebrotendinous xanthomatosis. Before treatment, all subjects… (More)
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