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Chenodeoxycholic Acid

Known as: Chenocholic acid, Chenodesoxycholic acid, Chenodiol 
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (21)

23-hydroxychenodeoxycholic acid23-norchenodeoxycholic acid24-norchenodeoxycholic acid3,7-dihydroxy-12-oxocholanoic acid

Broader (4)

Bile Acids and SaltsCatharticsDeoxycholic AcidGastrointestinal Agents
Drug AllergyIn BloodLiver diseasesPancreatitis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Consequences of bile salt biotransformations by intestinal bacteria
ABSTRACT Emerging evidence strongly suggest that the human “microbiome” plays an important role in both health and disease. Bile… 
Highly Cited
2013
Highly Cited
2013
Modulation of the fecal bile acid profile by gut microbiota in cirrhosis.
Highly Cited
2010
Highly Cited
2010
Inhibiting the Initiation of Clostridium difficile Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid
ABSTRACT To cause disease, Clostridium difficile spores must germinate in the host gastrointestinal tract. Germination is… 
Highly Cited
2008
Highly Cited
2008
Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms
Carbonic anhydrase, a zinc enzyme found in organisms from all kingdoms, catalyses the reversible hydration of carbon dioxide and… 
Highly Cited
2002
Highly Cited
2002
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
A series of 6alpha-alkyl-substituted analogues of chenodeoxycholic acid (CDCA) were synthesized and evaluated as potential… 
Highly Cited
1999
Highly Cited
1999
Bile acids: natural ligands for an orphan nuclear receptor.
Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly… 
Highly Cited
1999
Highly Cited
1999
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.
Highly Cited
1989
Highly Cited
1989
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
Highly Cited
1984
Highly Cited
1984
Long-term treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid.
We studied the effect of chenodeoxycholic acid in 17 patients with cerebrotendinous xanthomatosis. Before treatment, all subjects… 
Highly Cited
1972
Highly Cited
1972
Dissolution of cholesterol gallstones by chenodeoxycholic acid.
Abstract Seven women with gallstones were given 0.75 to 4.5 g per day of chenodeoxycholic acid, a primary bile acid, to promote… 
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