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Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics
The great variety of bile acids and bile alcohols that are present in vertebrates are tabulated and signaling molecules, activating nuclear receptors in the hepatocyte and ileal enterocyte, as well as an increasing number of G-protein coupled receptors are identified.
Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.
Inhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing Drugs
The study suggests that coexpressing cells can provide a useful system for the identification of inhibitors of these two transport systems, including potential drug candidates.
Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and…
The results suggest that UDCA and its conjugates are taken up by both multiple saturable transport systems and nonsaturable transport in human liver with different contributions.
High pressure liquid chromatographic analysis of conjugated bile acids in human bile: simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids.
The method has been applied to samples of gallbladder bile obtained from 14 healthy subjects to define the pattern of conjugated bile acids present in human bile.
Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem.
Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione.
- M. Rius, J. Hummel-Eisenbeiss, A. Hofmann, D. Keppler
- BiologyAmerican journal of physiology. Gastrointestinal…
- 1 April 2006
It is demonstrated that human ABCC4 in the presence of physiological concentrations of GSH has a high affinity for the taurine and glycine conjugates of the common natural bile acids as well as the unconjugated bile acid cholate.
Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium…
The influence of bile salt structure on self-association in aqueous solutions.
Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability, and morphology in the perfused rabbit colon.
- V. Chadwick, T. Gaginella, G. Carlson, J. Debongnie, S. Phillips, A. Hofmann
- Biology, ChemistryThe Journal of laboratory and clinical medicine
- 1 November 1979
It is shown that of the major primary and secondary bile acids in man, only deoxycholic and chenodeoxycholics acids alter colonic structure and function in the rabbit and that bile acid-induced secretion was invariably associated with increased mucosal permeability and epitheliolysis.