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The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver*
Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular identity of the involved ATP-dependent carrier protein has not been elucidated. We cloned theExpand
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The continuing importance of bile acids in liver and intestinal disease.
  • A. Hofmann
  • Medicine
  • Archives of internal medicine
  • 13 December 1999
Bile acids, the water-soluble, amphipathic end products of cholesterol metabolism, are involved in liver, biliary, and intestinal disease. Formed in the liver, bile acids are absorbed actively fromExpand
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Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics
Abstract.Bile acids and bile alcohols in the form of their conjugates are amphipathic end products of cholesterol metabolism with multiple physiological functions. The great variety of bile acids andExpand
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Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.
BACKGROUND & AIMS Based on a recently cloned rat liver organic anion transporter, we attempted to clone the corresponding human liver organic anion transporting polypeptide. METHODS A human liverExpand
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Bile Acids: The Good, the Bad, and the Ugly.
  • A. Hofmann
  • Biology, Medicine
  • News in physiological sciences : an international…
  • 1 February 1999
Bile acids, amphipathic end products of cholesterol metabolism, are "good" in the infant because they enhance lipid absorption and thereby promote growth. Bile acids also induce bile flow and biliaryExpand
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Bile salts of vertebrates: structural variation and possible evolutionary significance[S]
Biliary bile salt composition of 677 vertebrate species (103 fish, 130 reptiles, 271 birds, 173 mammals) was determined. Bile salts were of three types: C27 bile alcohols, C27 bile acids, or C24 bileExpand
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High pressure liquid chromatographic analysis of conjugated bile acids in human bile: simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids.
A reversed phase high pressure liquid chromatography (HPLC) system capable of simultaneously separating four lithocholyl species (sulfated and unsulfated forms of lithocholylglycine andExpand
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Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem.
The structure of the bile acid molecule is described and correlated with physiochemical properties of bile acids such as solubility, ionization, and micelle formation. Recent measurements of theExpand
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Inhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing Drugs
Vectorial transport of bile acids across hepatocytes is a major driving force for bile flow, and bile acid retention in the liver causes hepatotoxicity. The basolateral and apical transporters forExpand
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Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and
Ursodeoxycholate (UDCA) is widely used for the treatment of cholestatic liver disease. After oral administration, UDCA is absorbed, taken up efficiently by hepatocytes, and conjugated mainly withExpand
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