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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan. Expand
Biliary tract cancers.
- P. de Groen, G. Gores, N. LaRusso, L. Gunderson, D. Nagorney
- The New England journal of medicine
- 24 June 1999
In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually; about 5000 of these are gallbladder cancer, and between 2000 and 3000 are bile-duct cancers. Expand
The cholangiopathies: disorders of biliary epithelia.
Primary sclerosing cholangitis: Summary of a workshop
Significant opportunities remain for basic and clinical research into the cause, natural history, and therapy of PSC, which has several atypical features and a strong genetic component. Expand
The pathobiology of biliary epithelia
Investigators reviewed the status of the field of cholangiocyte pathobiology, identify new areas of interest, and propose future directions to improve understanding of ductal bile formation. Expand
Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis
Multivariate analysis (Cox proportional hazards regression modeling) revealed that age, serum bilirubin concentration, blood hemoglobin concentration, presence or absence of inflammatory bowel disease and histologic stage on liver biopsy were independent predictors of high risk of dying. Expand
Long‐term results of patients undergoing liver transplantation for primary sclerosing cholangitis
The data show that liver transplantation provides excellent long‐term patient and graft survival for patients with end‐stage PSC, and patients with associated inflammatory bowel disease did not adversely impact patient outcome posttransplantation. Expand
A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection*
- Xian-Ming Chen, P. Splinter, S. O’Hara, N. LaRusso
- Biology, Medicine
- Journal of Biological Chemistry
- 28 September 2007
The results indicate that let-7i regulates TLR4 expression in cholangiocytes and contributes to epithelial immune responses against C. parvum infection, raising the possibility that micro-RNA-mediated post-transcriptional pathways may be critical to host-cell regulatory responses to microbial infection in general. Expand
Characterization of PKD protein-positive exosome-like vesicles.
- M. Hogan, L. Manganelli, +12 authors C. Ward
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 1 February 2009
Proteomic analysis of PKD ELVs identified 552 proteins, many of which have been implicated in signaling, including the molecule Smoothened, which suggests that PKD proteins are shed in membrane particles in the urine, and these particles interact with primary cilia. Expand
Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver.
It is indicated that cholangiocytes are morphologically and functionally heterogeneous along the normal intrahepatic biliary tree and suggest that secretion-regulated transport of water and electrolytes occurs principally in medium and large ducts. Expand