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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and theExpand
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Biliary tract cancers.
In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually.1 Biliary tract cancer is the second most common primary hepatobiliary cancer, afterExpand
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The cholangiopathies: disorders of biliary epithelia.
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Primary sclerosing cholangitis: Summary of a workshop
Primary sclerosing cholangitis (PSC) is a rare but important liver disease that leads to cirrhosis and need for liver transplantation in a high proportion of cases. The disease occurs inExpand
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Characterization of PKD protein-positive exosome-like vesicles.
Proteins associated with autosomal dominant and autosomal recessive polycystic kidney disease (polycystin-1, polycystin-2, and fibrocystin) localize to various subcellular compartments, but theirExpand
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Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis
The natural history of primary sclerosing cholangitis was assessed in 174 patients; 37 were asymptomatic and 137 had symptoms related to underlying liver disease. At the time of diagnosis, the meanExpand
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A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection*
Toll-like receptors (TLRs) are important pathogen recognition molecules and are key to epithelial immune responses to microbial infection. However, the molecular mechanisms that regulate TLRExpand
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Long‐term results of patients undergoing liver transplantation for primary sclerosing cholangitis
Liver transplantation is the only effective therapeutic option for patients with end‐stage liver disease due to primary sclerosing cholangitis (PSC). In this study, we analyzed a single center'sExpand
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Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling.
BACKGROUND & AIMS Cholangiocytes have primary cilia extending from the apical plasma membrane into the ductal lumen. While the physiologic significance of cholangiocyte cilia is unknown, studies inExpand
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A revised natural history model for primary sclerosing cholangitis.
OBJECTIVE To describe a natural history model for primary sclerosing cholangitis (PSC) that is based on routine clinical findings and test results and eliminates the need for liver biopsy. PATIENTSExpand
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