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Ceramidase

Known as: N-Acylsphingosine Amidohydrolase, Ceramidases [Chemical/Ingredient], Ceramidases 
Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic… 
National Institutes of Health

Related topics

Related topics

9 relations
Acid CeramidaseIn BloodProcess of secretionantagonists & inhibitors

Broader (1)

Amidohydrolases

Papers overview

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Highly Cited
2013
Highly Cited
2013
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
The expression of acid ceramidase (AC) – a cysteine amidase that hydrolyses the proapoptotic lipid ceramide – is abnormally high… 
Highly Cited
2013
Highly Cited
2013
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and… 
Review
2007
Review
2007
Regulation and functional roles of sphingosine kinases
Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). Together with other… 
Highly Cited
2006
Highly Cited
2006
Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids*
Complex sphingolipids are abundant as eukaryotic cell membrane components, whereas their metabolites, in particular ceramide… 
Highly Cited
2005
Highly Cited
2005
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging
Abstract:  In aged skin, decreased levels of stratum corneum ceramides have been described. Epidermal ceramides are generated by… 
Highly Cited
1997
Highly Cited
1997
Characterization of Ceramide Synthesis
Ceramide (N-acylsphingosine) biosynthesis has been proposed to involve introduction of the 4,5-trans-double bond of sphingosine… 
Highly Cited
1997
Highly Cited
1997
Bimodal Regulation of Ceramidase by Interleukin-1β
Interleukin 1β (IL-1β) induces the hydrolysis of sphingomyelin (SM) to ceramide (Cer) in primary cultures of rat hepatocytes, and… 
Highly Cited
1997
Highly Cited
1997
Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma
The metabolism of sphingomyelin generates important signals regulating cell proliferation and apoptosis. Previous studies found… 
Review
1990
Review
1990
An update of the enzymology and regulation of sphingomyelin metabolism.
Highly Cited
1972
Highly Cited
1972
Ceramidase Deficiency in Farber's Disease (Lipogranulomatosis)
Ceramidase activity could not be demonstrated in the kidney and cerebellum from a deceased patient with Farber's disease, whereas… 
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