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Ceramidase

Known as: N-Acylsphingosine Amidohydrolase, Ceramidases [Chemical/Ingredient], Ceramidases 
Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic… 
National Institutes of Health

Related topics

Related topics

9 relations
Acid CeramidaseIn BloodProcess of secretionantagonists & inhibitors

Broader (1)

Amidohydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.
Highly Cited
2007
Highly Cited
2007
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy.
Head and neck squamous cell cancers (HNSCC) are particularly aggressive and are resistant to many forms of treatment. Ceramide… 
Review
2007
Review
2007
Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy.
Highly Cited
2003
Highly Cited
2003
O-Glycosylation of Mucin-like Domain Retains the Neutral Ceramidase on the Plasma Membranes as a Type II Integral Membrane Protein*
Ceramidase is a key enzyme involved in regulating cellular levels of ceramide, sphingosine, and possibly sphigosine 1-phosphate… 
Highly Cited
2001
Highly Cited
2001
Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney*
Previously, we reported two types of neutral ceramidase in mice, one solubilized by freeze-thawing and one not. The former was… 
Highly Cited
2001
Highly Cited
2001
Biochemical Characterization of the Reverse Activity of Rat Brain Ceramidase
We have previously purified a membrane-bound ceramidase from rat brain and recently cloned the human homologue. We also observed… 
Highly Cited
2000
Highly Cited
2000
Molecular Cloning of the Full-length cDNA Encoding Mouse Neutral Ceramidase
We report here the molecular cloning, sequencing, and expression of the gene encoding the mouse neutral ceramidase, which has… 
Highly Cited
2000
Highly Cited
2000
Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells*
Exposure to anti-Fas antibody in Jurkat cells (type II cells), which are characterized by a weak caspase-8 activation at the… 
Highly Cited
1997
Highly Cited
1997
Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma
The metabolism of sphingomyelin generates important signals regulating cell proliferation and apoptosis. Previous studies found… 
Highly Cited
1989
Highly Cited
1989
Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum.
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