XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response
It is concluded that specific and direct interactions between ATF6 and ERSE are critical for transcriptional induction not only of ER chaperones but also of CHOP and XBP-1.
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
It is proposed that nuclear- localized IRE1alpha and cytoplasmic-localized ATF6 signaling pathways merge through regulation of XBP1 activity to induce downstream gene expression.
Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins
- H. Yoshida, K. Haze, H. Yanagi, T. Yura, K. Mori
- BiologyJournal of Biological Chemistry
- 11 December 1998
The results suggest that, as in yeast, bZIP proteins are involved in mammalian UPR, acting through newly defined ERSE,acting through newlydefined ERSE.
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
This work provides new insight into how a stress response pathway can be structured to allow cells to avert death as they adapt and underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome.
A time-dependent phase shift in the mammalian unfolded protein response.
Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb.
The mechanism of olfactory discrimination by single unit recordings of responses to a series of normal aliphatic aldehydes from individual rabbit M/T cells was investigated and revealed that inhibitory responses are evoked in a M/ T cell by a defined subset of odor molecules with structures closely related to the excitatory odor molecules.
Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum
- K. Mori
- 26 May 2000
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.
- K. Hirota, M. Matsui, S. Iwata, A. Nishiyama, K. Mori, J. Yodoi
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 15 April 1997
It is proved that TRX can associate directly with Ref-1 in the nucleus and the requirement of cysteine residues in the TRX catalytic center for the potentiation of AP-1 activity is demonstrated.