Acid Ceramidase

Known as: AC, Acid Ceramidase [Chemical/Ingredient], Acylsphingosine Deacylase 
A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
0102019652017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease (AD). To extend these findings, several… (More)
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2008
2008
Herein we report the mechanism of human acid ceramidase (AC; N-acylsphingosine deacylase) cleavage and activation. A highly… (More)
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2008
2008
Extracellular calcium (Ca2+(o)) potently induces the growth arrest and differentiation of human epidermal keratinocytes (HEKs… (More)
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Highly Cited
2007
Highly Cited
2007
Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established… (More)
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2006
2006
Treatment of different cancer cell lines with desipramine induced a time- and dose-dependent downregulation of acid ceramidase… (More)
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Highly Cited
2005
Highly Cited
2005
Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation of lipids in tissues not suited… (More)
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2003
2003
An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide… (More)
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2001
2001
The biosynthesis of human acid ceramidase (hAC) starts with the expression of a single precursor polypeptide of approximately 53… (More)
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Highly Cited
2000
Highly Cited
2000
The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered in several cancers… (More)
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1995
1995
Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) is the lysosomal enzyme catalyzing the hydrolysis of ceramide to… (More)
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