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Acid Ceramidase

Known as: AC, Acid Ceramidase [Chemical/Ingredient], Acylsphingosine Deacylase 
A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of… Expand
National Institutes of Health

Related topics

Related topics

19 relations
ASAH1 geneAlkaline Ceramidase 2Cavity of lysosomeCeramidase
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Papers overview

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Highly Cited
2016
Highly Cited
2016
Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases.
Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid… Expand
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2013
2013
Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.
Acid ceramidase (AC), EC 3.5.1.23, a lysosomal enzyme, catalyzes the hydrolysis of ceramide to constituent sphingoid base… Expand
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Highly Cited
2011
Highly Cited
2011
Genistein Stimulates MCF-7 Breast Cancer Cell Growth by Inducing Acid Ceramidase (ASAH1) Gene Expression*
Sphingolipid metabolites, such as ceramide (Cer), sphingosine (SPH), and sphingosine 1-phosphate (S1P), contribute to multiple… Expand
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Highly Cited
2011
Highly Cited
2011
C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth
The sphingolipid ceramide is known to play a central role in chemo- and radiation-induced cell death. Acid ceramidase (AC… Expand
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Review
2010
Review
2010
Fatty acid 2-Hydroxylation in mammalian sphingolipid biology.
  • Hiroko Hama
  • Biochimica et biophysica acta
  • 2010
    • Corpus ID: 25477860
2-Hydroxy fatty acids (hFA) are important components of a subset of mammalian sphingolipids. The presence of hFA in sphingolipids… Expand
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Highly Cited
2006
Highly Cited
2006
New insights on the use of desipramine as an inhibitor for acid ceramidase.
Treatment of different cancer cell lines with desipramine induced a time- and dose-dependent downregulation of acid ceramidase… Expand
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Highly Cited
2005
Highly Cited
2005
Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling*
Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation of lipids in tissues not suited… Expand
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Highly Cited
2003
Highly Cited
2003
Purification and Characterization of Recombinant, Human Acid Ceramidase
Human acid ceramidase was overexpressed in Chinese hamster ovary cells by amplification of the transfected, full-length cDNA. The… Expand
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Highly Cited
2000
Highly Cited
2000
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered in several cancers… Expand
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Highly Cited
1995
Highly Cited
1995
Purification, characterization, and biosynthesis of human acid ceramidase
Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) is the lysosomal enzyme catalyzing the hydrolysis of ceramide to… Expand
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