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Acid Ceramidase

Known as: AC, Acid Ceramidase [Chemical/Ingredient], Acylsphingosine Deacylase 
A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid… Expand
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2013
2013
Acid ceramidase (AC), EC 3.5.1.23, a lysosomal enzyme, catalyzes the hydrolysis of ceramide to constituent sphingoid base… Expand
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Highly Cited
2011
Highly Cited
2011
Sphingolipid metabolites, such as ceramide (Cer), sphingosine (SPH), and sphingosine 1-phosphate (S1P), contribute to multiple… Expand
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Highly Cited
2011
Highly Cited
2011
The sphingolipid ceramide is known to play a central role in chemo- and radiation-induced cell death. Acid ceramidase (AC… Expand
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Review
2010
Review
2010
  • Hiroko Hama
  • Biochimica et biophysica acta
  • 2010
  • Corpus ID: 25477860
2-Hydroxy fatty acids (hFA) are important components of a subset of mammalian sphingolipids. The presence of hFA in sphingolipids… Expand
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Highly Cited
2006
Highly Cited
2006
Treatment of different cancer cell lines with desipramine induced a time- and dose-dependent downregulation of acid ceramidase… Expand
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Highly Cited
2005
Highly Cited
2005
Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation of lipids in tissues not suited… Expand
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Highly Cited
2003
Highly Cited
2003
Human acid ceramidase was overexpressed in Chinese hamster ovary cells by amplification of the transfected, full-length cDNA. The… Expand
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Highly Cited
2000
Highly Cited
2000
The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered in several cancers… Expand
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Highly Cited
1995
Highly Cited
1995
Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) is the lysosomal enzyme catalyzing the hydrolysis of ceramide to… Expand
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