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Acid Ceramidase

Known as: AC, Acid Ceramidase [Chemical/Ingredient], Acylsphingosine Deacylase 
A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of… 
National Institutes of Health

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ASAH1 geneAlkaline Ceramidase 2Cavity of lysosomeCeramidase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Development of an acid ceramidase activity-based probe.
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into… 
2014
2014
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
2011
2011
Clinical Utility of Serum Autoantibodies Detected by Protein Microarray in Melanoma
Better prognostic and predictive markers in melanoma are needed to select patients for therapy. We utilized a dual-lectin… 
2008
2008
Population Genetic Analysis of the N-Acylsphingosine Amidohydrolase Gene Associated With Mental Activity in Humans
To understand the evolution of human mental activity, we performed population genetic analyses of nucleotide sequences (∼11 kb… 
2007
2007
Overexpression and mass spectrometry analysis of mature human acid ceramidase
Abstract Human acid ceramidase catalyzes the last step of lysosomal sphingolipid degradation, the hydrolysis of ceramide to… 
1997
1997
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies.
1987
1987
Farber's disease (lysosomal acid ceramidase deficiency).
The patient presented with progressive joint deformity, a hoarse voice, subsequent cachexia, and myoclonic seizures. She was… 
Highly Cited
1986
Highly Cited
1986
Acid and alkaline ceramidases of rat tissues.
Ceramidase (N-acylsphingosine deacylase) was measured in rat tissue homogenates with N-[1-14C]oleoyl- and N-[9,10-3H]palmitoyl… 
1981
1981
Role of lysosomal acid ceramidase in the metabolism of ceramide in human skin fibroblasts.
1976
1976
Diagnosis of lipogranulomatosis (Farber disease) by use of cultured fibroblasts.
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