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Acid Ceramidase

Known as: AC, Acid Ceramidase [Chemical/Ingredient], Acylsphingosine Deacylase 
A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of… 
National Institutes of Health

Related topics

Related topics

19 relations
ASAH1 geneAlkaline Ceramidase 2Cavity of lysosomeCeramidase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Acid ceramidase deficiency: Farber disease and SMA-PME
Acid ceramidase (ACDase) deficiency is a spectrum of disorders that includes a rare lysosomal storage disorder called Farber… 
Highly Cited
2016
Highly Cited
2016
Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases
Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid… 
Highly Cited
2015
Highly Cited
2015
Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia
Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death… 
Highly Cited
2012
Highly Cited
2012
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Review
2010
Review
2010
Fatty acid 2-Hydroxylation in mammalian sphingolipid biology.
  • H. Hama
  • Biochimica et biophysica acta
  • 2010
  • Corpus ID: 25477860
Review
2006
Review
2006
Acid ceramidase and human disease.
Highly Cited
2005
Highly Cited
2005
Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling*
Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation of lipids in tissues not suited… 
Highly Cited
2003
Highly Cited
2003
Purification and Characterization of Recombinant, Human Acid Ceramidase
Human acid ceramidase was overexpressed in Chinese hamster ovary cells by amplification of the transfected, full-length cDNA. The… 
Highly Cited
2000
Highly Cited
2000
Human acid ceramidase is overexpressed but not mutated in prostate cancer
The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered in several cancers… 
Highly Cited
1995
Highly Cited
1995
Purification, characterization, and biosynthesis of human acid ceramidase
Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23) is the lysosomal enzyme catalyzing the hydrolysis of ceramide to… 
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