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Cathepsins

Known as: Cathepsin, Cathepsins [Chemical/Ingredient] 
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin… 
National Institutes of Health

Related topics

Related topics

26 relations

Broader (2)

Aspartic Acid Endopeptidasescaspase

Narrower (10)

Cathepsin ECtso protein, mousecat-L1B protein, Fasciola giganticacathepsin S
Enzyme GeneHydrolysisIn BloodPeptidase Gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
TLR3, TLR7, and TLR9 are cleaved in the same step-wise manner in all immune cell types examined. 
Highly Cited
2006
Highly Cited
2006
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and… 
Highly Cited
2004
Highly Cited
2004
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles.
Highly Cited
2004
Highly Cited
2004
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
AbstractAcidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these… 
Highly Cited
2000
Highly Cited
2000
Generation and degradation of human endostatin proteins by various proteinases
Highly Cited
2000
Highly Cited
2000
Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts.
Highly Cited
1999
Highly Cited
1999
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome
Papillon-Lefèvre syndrome (PLS) is an autosomal recessive disorder characterised by palmoplantar hyperkeratosis and severe early… 
Review
1995
Review
1995
Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Highly Cited
1993
Highly Cited
1993
β-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo
Highly Cited
1992
Highly Cited
1992
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.
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