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Cathepsins

Known as: Cathepsin, Cathepsins [Chemical/Ingredient] 
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin… 
National Institutes of Health

Related topics

Related topics

26 relations

Broader (2)

Aspartic Acid Endopeptidasescaspase

Narrower (10)

Cathepsin ECtso protein, mousecat-L1B protein, Fasciola giganticacathepsin S
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Enzyme GeneHydrolysisIn BloodPeptidase Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Osteoporosis: now and the future
Review
2010
Review
2010
Specialized roles for cysteine cathepsins in health and disease.
Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for… 
Review
2006
Review
2006
Cysteine cathepsins: multifunctional enzymes in cancer
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post… 
Review
2006
Review
2006
Innate immunity of fish (overview).
Highly Cited
2005
Highly Cited
2005
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no… 
Highly Cited
1998
Highly Cited
1998
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix… 
Highly Cited
1998
Highly Cited
1998
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a… 
Highly Cited
1996
Highly Cited
1996
Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency
Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature, maps to… 
Highly Cited
1995
Highly Cited
1995
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial…
We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage… 
Highly Cited
1938
Highly Cited
1938
THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN
  • M. L. Anson
  • The Journal of general physiology
  • 1938
  • Corpus ID: 15231783
In the hemoglobin method for the estimation of proteinase, denatured hemoglobin is digested under standard conditions, the… 
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