Cathepsins

Known as: Cathepsin, Cathepsins [Chemical/Ingredient] 
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin… (More)
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune… (More)
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Review
2012
Review
2012
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which are enclosed in the lysosomes, help to… (More)
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Highly Cited
2007
Highly Cited
2007
Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery… (More)
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Review
2006
Review
2006
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post… (More)
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Highly Cited
2004
Highly Cited
2004
Tumors develop through successive stages characterized by changes in gene expression and protein function. Gene expression… (More)
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Review
2001
Review
2001
Nuclear DNA damage and ligation of plasma-membrane death receptors have long been recognized as initial triggers of apoptosis… (More)
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Highly Cited
1998
Highly Cited
1998
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix… (More)
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Highly Cited
1998
Highly Cited
1998
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a… (More)
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Highly Cited
1998
Highly Cited
1998
Type I collagen fibers account for 90% of the organic matrix of bone. The degradation of this collagen is a major event during… (More)
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Highly Cited
1938
Highly Cited
1938
In the hemoglobin method for the estimation of proteinase, denatured hemoglobin is digested under standard conditions, the… (More)
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