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Cathepsins

Known as: Cathepsin, Cathepsins [Chemical/Ingredient] 
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin… Expand
National Institutes of Health

Related topics

Related topics

26 relations

Broader (2)

Aspartic Acid Endopeptidasescaspase

Narrower (10)

Cathepsin ECtso protein, mousecat-L1B protein, Fasciola giganticacathepsin S
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Enzyme GeneHydrolysisIn BloodPeptidase Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Lysosomal membrane permeabilization and cell death.
Lysosomes are membrane-enclosed organelles that mediate the intracellular degradation of macromolecules. They play an essential… Expand
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Review
2015
Review
2015
Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis
Abstract Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses that infect a wide range… Expand
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Review
2006
Review
2006
Cysteine cathepsins: multifunctional enzymes in cancer
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post… Expand
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Highly Cited
1998
Highly Cited
1998
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix… Expand
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Highly Cited
1998
Highly Cited
1998
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a… Expand
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Highly Cited
1998
Highly Cited
1998
Silicatein α: Cathepsin L-like protein in sponge biosilica
Earth’s biota produces vast quantities of polymerized silica at ambient temperatures and pressures by mechanisms that are not… Expand
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Highly Cited
1996
Highly Cited
1996
Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency
Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature, maps to… Expand
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Highly Cited
1996
Highly Cited
1996
Proteolytic Activity of Human Osteoclast Cathepsin K
Human cathepsin K is a recently identified protein with high primary sequence homology to members of the papain cysteine protease… Expand
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Highly Cited
1995
Highly Cited
1995
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial…
We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage… Expand
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Highly Cited
1938
Highly Cited
1938
THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN
  • M. L. Anson
  • The Journal of general physiology
  • 1938
    • Corpus ID: 15231783
In the hemoglobin method for the estimation of proteinase, denatured hemoglobin is digested under standard conditions, the… Expand
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