Cathepsins

Known as: Cathepsin, Cathepsins [Chemical/Ingredient] 
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin… (More)
National Institutes of Health

Related topics

Related topics

26 relations

Broader (2)

Aspartic Acid Endopeptidasescaspase

Narrower (10)

Cathepsin ECtso protein, mousecat-L1B protein, Fasciola giganticacathepsin S
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Enzyme GeneHydrolysisIn BloodPeptidase Gene
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Papers overview

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Review
2016
Review
2016
New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation
Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune… (More)
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Review
2012
Review
2012
Lysosomes and lysosomal cathepsins in cell death.
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which are enclosed in the lysosomes, help to… (More)
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Highly Cited
2007
Highly Cited
2007
A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy
Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery… (More)
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Review
2006
Review
2006
Cysteine cathepsins: multifunctional enzymes in cancer
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post… (More)
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Highly Cited
2004
Highly Cited
2004
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
Tumors develop through successive stages characterized by changes in gene expression and protein function. Gene expression… (More)
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Review
2001
Review
2001
Organelle-specific initiation of cell death pathways
Nuclear DNA damage and ligation of plasma-membrane death receptors have long been recognized as initial triggers of apoptosis… (More)
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Highly Cited
1998
Highly Cited
1998
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix… (More)
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Highly Cited
1998
Highly Cited
1998
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a… (More)
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Highly Cited
1998
Highly Cited
1998
The collagenolytic activity of cathepsin K is unique among mammalian proteinases.
Type I collagen fibers account for 90% of the organic matrix of bone. The degradation of this collagen is a major event during… (More)
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Highly Cited
1938
Highly Cited
1938
THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN
In the hemoglobin method for the estimation of proteinase, denatured hemoglobin is digested under standard conditions, the… (More)
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