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Cathepsins
Known as:
Cathepsin
, Cathepsins [Chemical/Ingredient]
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin…
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National Institutes of Health
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Related topics
Related topics
26 relations
Broader (2)
Aspartic Acid Endopeptidases
caspase
Narrower (10)
Cathepsin E
Ctso protein, mouse
cat-L1B protein, Fasciola gigantica
cathepsin S
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Enzyme Gene
Hydrolysis
In Blood
Peptidase Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Osteoporosis: now and the future
T. Rachner
,
S. Khosla
,
L. Hofbauer
The Lancet
2011
Corpus ID: 8874666
Review
2010
Review
2010
Specialized roles for cysteine cathepsins in health and disease.
J. Reiser
,
B. Adair
,
T. Reinheckel
The Journal of clinical investigation
2010
Corpus ID: 8321343
Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for…
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Review
2006
Review
2006
Cysteine cathepsins: multifunctional enzymes in cancer
M. Mohamed
,
Bonnie F. Sloane
Nature Reviews Cancer
2006
Corpus ID: 26463930
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post…
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Review
2006
Review
2006
Innate immunity of fish (overview).
B. Magnadóttir
Fish & shellfish immunology
2006
Corpus ID: 8244896
Highly Cited
2005
Highly Cited
2005
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
G. Simmons
,
D. Gosalia
,
Andrew J Rennekamp
,
J. Reeves
,
S. Diamond
,
P. Bates
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 2484725
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no…
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Highly Cited
1998
Highly Cited
1998
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.
G. Sukhova
,
G. Shi
,
D. Simon
,
H. Chapman
,
P. Libby
The Journal of clinical investigation
1998
Corpus ID: 1032052
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix…
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Highly Cited
1998
Highly Cited
1998
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
P. Saftig
,
E. Hunziker
,
+6 authors
K. von Figura
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 1135362
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a…
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Highly Cited
1996
Highly Cited
1996
Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency
B. Gelb
,
G. Shi
,
H. Chapman
,
R. Desnick
Science
1996
Corpus ID: 7188076
Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature, maps to…
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Highly Cited
1995
Highly Cited
1995
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial…
F. Sallusto
,
M. Cella
,
C. Danieli
,
A. Lanzavecchia
The Journal of experimental medicine
1995
Corpus ID: 915702
We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage…
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Highly Cited
1938
Highly Cited
1938
THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN
M. L. Anson
The Journal of general physiology
1938
Corpus ID: 15231783
In the hemoglobin method for the estimation of proteinase, denatured hemoglobin is digested under standard conditions, the…
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