cathepsin S
National Institutes of Health
Papers overview
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Multiple cancer cells highly express cathepsin S, which has pro-tumoral effects. However, it was previously unknown whether…
AIMS
Cathepsin S is highly expressed in various cancer cells, and it has protumoral effects, including promotion of migration…
Metastasis remains the most common cause of death in most cancers, with limited therapies for combating disseminated disease…
Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine…
Cathepsin S (CatS) is a cysteine protease normally present in lysosomes. It has long been regarded as an enzyme that is primarily…
A series of small molecules bearing an alpha-ketoamide warhead were synthesized and evaluated for their ability to inhibit…
BACKGROUND
Cathepsin S and its endogenous inhibitor cystatin C are implicated in the pathogenesis of atherosclerosis, especially…
Previous studies have suggested that the production of cathepsin S (CatS), a cysteine protease, was specifically induced in…
Cysteine lysosomal proteases are essential for turnover of intracellular and extracellular proteins. These enzymes are strongly…