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Carcinogenic Nitrosourea

Any of several chemically related nitrosourea-derivates that increases the risk of human cancer and are highly lipid-soluble and act by alkylation… 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions.
1992
1992
Sulfotransferase-mediated DNA binding of N-hydroxyarylamines(amide) in liver cytosols from human and experimental animals.
Characteristics of cytosolic sulfotransferase-mediated binding of carcinogenic N-hydroxyarylamines(amide) have been investigated… 
1989
1989
INVOLVEMENT OF MICROSOMAL CYTOCHROME P-450 IN THE MUTAGENIC ACTIVATION OF 9 CARCINOGENIC N-NITROSOPROPYLAMINE DERIVATIVES BY LIVER S9 FROM 5 ANIMAL SPECIES AND MAN
1986
1986
Mutagenic activation of carcinogenic N-nitrosopropylamines by liver S9 fractions from mice, rats and hamsters: evidence for a cytochrome P-450-dependent reaction.
The mutagenic potential of nine carcinogenic N-nitrosopropylamines was examined by Ames preincubation assay using liver 9000 g… 
1986
1986
A comparative study of the mutagenic activation of N-nitrosopropylamines by various animal species and man: evidence for a cytochrome P-450 dependent reaction.
The mutagenic potential of seven carcinogenic N-nitrosopropylamines was examined by means of Ames' preincubation assay using… 
1985
1985
Mutagenic activation of carcinogenic N-nitrosopropylamines by rat liver: evidence for a cytochrome P-450 dependent reaction.
Mutagenic potential of carcinogenic N-nitrosopropylamines was examined by the Ames's liquid incubation assay, using rat liver… 
1981
1981
[Nitrosatable drugs (author's transl)].
  • D. Ziebarth
  • Archiv fur Geschwulstforschung
  • 1981
  • Corpus ID: 8706610
Out of 61 drugs, considered to be potentially nitrosatable on the basis of their chemical structure and being used for oral… 
Review
1971
Review
1971
Metabolic activation of N-hydroxy compounds by conjugation.
  • C. Irving
  • Xenobiotica; the fate of foreign compounds in…
  • 1971
  • Corpus ID: 796388
Abstract1. Conjugation of N-hydroxy-N-arylacetamides results in the metabolic activation of this class of compounds.2. This paper… 
1964
1964
E-8-3 Concerning the Highly Carcinogenic F-Norsteranthrene(Steroids)
1958
1958
Effect of Diphosphopyridine Nucleotide on the Inhibition of Rat Liver 3-Hydroxy-anthranilic-Acid Oxidase by 2-Acetyl-aminofluorene and N-2-Fluorenyl-diacetamide
DUNNING et al.1 demonstrated that bladder cancer due to 2-acetylaminofluorene was produced in almost all rats (strain Fisher 344… 
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