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- Publications
- Influence
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.
- G. Takayama, K. Arima, +7 authors K. Izuhara
- Medicine
- The Journal of allergy and clinical immunology
- 1 July 2006
BACKGROUND
Subepithelial fibrosis is a cardinal feature of bronchial asthma. Collagen I, III, and V; fibronectin; and tenascin-C are deposited in the lamina reticularis. Extensive evidence supports… Expand
Prostaglandin D2 as a mediator of allergic asthma.
- T. Matsuoka, M. Hirata, +15 authors S. Narumiya
- Medicine
- Science
- 17 March 2000
Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce type 2 (TH2) cytokines and is characterized by infiltration of eosinophils and bronchial… Expand
Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
- D. Hata, Y. Kawakami, +14 authors T. Kawakami
- Biology, Medicine
- The Journal of experimental medicine
- 20 April 1998
We investigated the role of Bruton's tyrosine kinase (Btk) in FcεRI-dependent activation of mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, mast cell development is… Expand
The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway…
- Noriyuki Yamamoto, Keisuke Takeshita, +8 authors K. Bacon
- Medicine
- Journal of Pharmacology and Experimental…
- 1 September 2003
Spleen tyrosine kinase (Syk) tyrosine kinase plays essential roles in receptors for Fc portion of immunoglobulins and B cell receptor complex signaling in various inflammatory cells; therefore,… Expand
Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease1
- Isao Nakao, S. Kanaji, +24 authors K. Izuhara
- Medicine
- The Journal of Immunology
- 1 May 2008
Excessive production of airway mucus is a cardinal feature of bronchial asthma and chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality in these diseases. IL-13, a… Expand
An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model
- T. Kobayashi, T. Miura, +4 authors K. Ishizaka
- Medicine
- The Journal of Immunology
- 1 April 2000
Immunization of BALB/c mice with alum-adsorbed OVA, followed by three bronchoprovocations with aerosolized OVA, resulted in the development of airway hyperresponsiveness (AHR) and allergic… Expand
Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice.
- H. Tanaka, M. Komai, +5 authors H. Nagai
- Medicine
- American journal of respiratory cell and…
- 19 February 2004
Asthma is a chronic inflammatory disease characterized by variable bronchial obstruction, hyperresponsiveness, and by tissue damage known as airway remodeling. In the present study we demonstrate… Expand
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice
- Y. Takahashi, S. Tokuoka, +6 authors H. Nagai
- Medicine
- British journal of pharmacology
- 1 October 2002
To evaluate the role of prostaglandin I2 (PGI2) in allergic inflammation, allergic responses in the airway, skin and T cells were studied in mice lacking the receptor for PGI2 (the prostanoid IP… Expand
Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice
- Asaka Saito, H. Tanaka, +5 authors H. Nagai
- Chemistry, Medicine
- Environmental toxicology
- 1 June 2011
Volatile organic compounds (VOCs) are considered the main cause of sick building syndrome and they are likely to irritate the skin, eyes, and mucous membrane; however, the toxic threshold and the… Expand
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
- T. Kunikata, H. Yamane, +7 authors S. Narumiya
- Chemistry, Medicine
- Nature Immunology
- 9 December 2005
Prostaglandins, including PGD2 and PGE2, are produced during allergic reactions. Although PGD2 is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis… Expand
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