Share This Author
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.
Prostaglandin D2 as a mediator of allergic asthma.
PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and is investigated by the generation of mice deficient in the PGD receptor (DP).
Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
An important role for Btk is demonstrated in the full expression of FcεRI signal transduction in mast cells, as confirmed by the improvement in the ability of btk mutant mast cells to degranulate and to secrete cytokines after the retroviral transfer of wild-type btk cDNA.
The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway…
- Noriyuki Yamamoto, Keisuke Takeshita, K. Bacon
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 September 2003
It was demonstrated that Syk may play a very critical role in the pathogenesis of allergic reactions and was identified as a potent and selective inhibitor of Syk kinase.
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
Mice lacking EP3 developed allergic inflammation that was much more pronounced than that in wild-type mice or mice deficient in other prostaglandin E receptor subtypes and an EP3-selective agonist suppressed the inflammation.
An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model
The results suggested that AHR could be developed by two distinct cellular mechanisms, one would go through mast cell activation and the other is IgE/mast cell independent but an eosinophil/IL-5-dependent mechanism.
Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice.
- Hiroyuki Tanaka, M. Komai, H. Nagai
- Medicine, BiologyAmerican journal of respiratory cell and…
- 19 February 2004
It is demonstrated that eosinophils are involved in allergen-induced subepithelial and peribronchial fibrosis probably by producing a fibrogenic factor, TGF-beta1.
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity
Physical interaction of T cells and dendritic cells (DCs) is essential for T cell proliferation and differentiation, but it has been unclear how this interaction is regulated physiologically. Here we…
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice
- Yoshimasa Takahashi, S. Tokuoka, H. Nagai
- Biology, MedicineBritish journal of pharmacology
- 1 October 2002
The present data indicate that IP receptor deficiency reinforced an allergic airway and skin inflammation by augmentation of vascular permeability increase and the T helper 2 cell function, suggesting a regulatory role of PGI2 in allergic inflammation.
Scratching Behavior in Various Strains of Mice
- N. Inagaki, M. Nagao, K. Igeta, H. Kawasaki, Jhon Fan Kim, H. Nagai
- Biology, PsychologySkin Pharmacology and Physiology
- 1 April 2001
The results suggest that the ICR mouse is a good responder for scratching behavior against various stimuli, especially against histamine, and may be suitable for studying mediators and/or mechanisms for itching.