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Captopril

Known as: CPT, Captoprilum, (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline 
A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits… 
National Institutes of Health

Related topics

Related topics

44 relations

Broader (5)

Amino Acids, CyclicAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEnzyme Inhibitors
AngioedemaAngiotensin-Converting Enzyme Inhibitors [MoA]AngiotensinsBartter Disease

Narrower (16)

ApoprilCapotenCaptolaneCaptopril / Hydrochlorothiazide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.
Angiotensin converting enzyme (ACE) plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well… 
Highly Cited
1997
Highly Cited
1997
Increased Probability of GABA Release during Withdrawal from Morphine
Opioid receptors located on interneurons in the ventral tegmental area (VTA) inhibit GABAA-mediated synaptic transmission to… 
Highly Cited
1992
Highly Cited
1992
Left ventricular remodeling in the year after first anterior myocardial infarction: a quantitative analysis of contractile segment lengths and ventricular shape.
Highly Cited
1991
Highly Cited
1991
Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin-converting-enzyme inhibition
Highly Cited
1991
Highly Cited
1991
History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme
In describing the development of captopril and related antihypertensive drugs, we hope to resurrect a more specific meaning for… 
Highly Cited
1990
Highly Cited
1990
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.
The effects of 9 months of orally administered captopril (25-50 mg/kg body wt/day) on aortic atherosclerosis was examined in… 
Highly Cited
1985
Highly Cited
1985
Effect of captopril on heavy proteinuria in azotemic diabetics.
We investigated whether captopril, an angiotensin-converting-enzyme inhibitor, would reduce proteinuria in patients with advanced… 
Highly Cited
1984
Highly Cited
1984
Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase
Highly Cited
1980
Highly Cited
1980
Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man.
Captopril is a potent hypotensive agent whose efficacy has hitherto been attributed to its ability to alter either angiotensin II… 
Review
1979
Review
1979
CAPTOPRIL IN THE TREATMENT OF CLINICAL HYPERTENSION AND CARDIAC FAILURE
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