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CYP8B1 protein, human

Known as: Steroid 12-Alpha-Hydroxylase, Cytochrome P450 Family 8 Subfamily B Polypeptide 1, 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase 
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (501 aa, ~58 kDa) is encoded by the human CYP8B1 gene. This protein is involved in bile acid… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD) is characterized by dysbiosis. The bidirectional effects between… Expand
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Highly Cited
2008
Highly Cited
2008
Liver receptor homolog 1 (LRH-1), an orphan nuclear receptor, is highly expressed in liver and intestine, where it is implicated… Expand
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Highly Cited
2006
Highly Cited
2006
Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver. Mice lacking… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT SHP has been implicated as a pleiotropic regulator of diverse biological functions by its ability to inhibit numerous… Expand
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Review
2005
Review
2005
Drugs and bile acids are taken up into hepatocytes by specialized transport proteins localized at the basolateral membrane, e.g… Expand
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Highly Cited
2005
Highly Cited
2005
We have generated a line of mutant mouse that lacks betaKlotho, a protein that structurally resembles Klotho. The synthesis and… Expand
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Highly Cited
2003
Highly Cited
2003
The orphan nuclear hormone receptor SHP (gene designation NROB2) is an important component of a negative regulatory cascade by… Expand
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Highly Cited
2001
Highly Cited
2001
Sterol 12alpha-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic… Expand
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Highly Cited
1999
Highly Cited
1999
Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic… Expand
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1999
1999
Sterol 12alpha-hydroxylase (CYP 8B1) is a microsomal cytochrome P450 enzyme involved in bile acid synthesis that is of critical… Expand
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