Sterol 12-alpha-Hydroxylase

Known as: Steroid 12-alpha-Hydroxylase, Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating), 12alpha-Hydroxylase 
A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular… (More)
National Institutes of Health

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2012
2012
Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide. Overnutrition and insulin… (More)
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Highly Cited
2007
Highly Cited
2007
Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR… (More)
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Highly Cited
2007
Highly Cited
2007
Bile acids (BAs) are water-soluble end products from cholesterol metabolism and are essential for efficient absorption of dietary… (More)
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2007
2007
The transport and metabolism of xenobiotics is controlled by the drug transporters and drug-metabolizing enzymes in the liver and… (More)
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2007
Highly Cited
2007
BACKGROUND Bile acid synthesis, transport and metabolism are markedly altered in experimental cholestasis. Whether such… (More)
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2003
Highly Cited
2003
Guggulipid is an extract of the guggul tree Commiphora mukul and has been widely used to treat hyperlipidemia in humans. The… (More)
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2003
2003
The orphan nuclear hormone receptor SHP (gene designation NROB2) is an important component of a negative regulatory cascade by… (More)
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2001
Highly Cited
2001
Sterol 12alpha-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic… (More)
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Highly Cited
2000
Highly Cited
2000
Fibrates are a group of hypolipidemic agents that efficiently lower serum triglyceride levels by affecting the expression of many… (More)
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2000
2000
Cholesterol conversion to bile acids occurs via the "classic" (neutral) or the "alternative" (acidic) bile acid biosynthesis… (More)
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