Skip to search formSkip to main contentSkip to account menu

CYP8B1 gene

Known as: cytochrome P450 family 8 subfamily B member 1, CYP8B1, STEROL 12-ALPHA-HYDROXYLASE 
This gene plays a role in steroid metabolism and regulation of cholesterol solubility.
National Institutes of Health

Related topics

Related topics

8 relations
CYP8B1 protein, humanCYP8B1 wt AlleleIron ChelationMetabolic Detoxication, Drug

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with…
Anabolic–androgenic steroids are testosterone derivatives, used by body-builders to increase muscle mass. Epistane (EPI) is an… 
2019
2019
A Possible Mechanism of Metformin in Improving Insulin Resistance in Diabetic Rat Models
Background Type 2 diabetes has become one of the most common diseases worldwide, causing a serious social burden. As a first-line… 
2019
2019
Signatures of relaxed selection in the CYP8B1 gene of birds and mammals
The CYP8B1 gene is known to catalyse reactions that determine the ratio of primary bile salts and the loss of this gene has… 
2019
2019
Identification of prognostic biomarkers for patients withhepatocellular carcinoma after hepatectomy
Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of… 
2018
2018
Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects
BackgroundRitodrine is a commonly used tocolytic to prevent preterm labour. However, it can cause unexpected serious adverse… 
2013
2013
Single nucleotide polymorphism rs3732860 in the 3′‐untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese
Gallstone disease (GD) is a common disease of multigenetic origin; however, the major susceptibility loci for GD in human… 
2007
2007
Superactivity and dual reactivity of the system N-iodosuccinimide-H2SO4 in the iodination of deactivated arenes
Dissolution of N-iodosuccinimide in sulfuric acid gives rise to electrophilic iodine-containing species which are capable of… 
Highly Cited
2006
Highly Cited
2006
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver. Mice lacking… 
Highly Cited
2006
Highly Cited
2006
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice Published, JLR Papers in Press, November 1, 2005.
As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1−/−) fail to produce cholic acid (CA… 
2006
2006
Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprits⃞ Published, JLR Papers in Press, June 8, 2006.
An intercross between C57BL/6J and CASA/Rk mice was used to study the genetics of biliary bile acid composition. In parental… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License