CYP8B1 gene

Known as: cytochrome P450 family 8 subfamily B member 1, CYP8B1, STEROL 12-ALPHA-HYDROXYLASE 
This gene plays a role in steroid metabolism and regulation of cholesterol solubility.
National Institutes of Health

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CYP8B1 protein, humanCYP8B1 wt AlleleIron ChelationMetabolic Detoxication, Drug
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Papers overview

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2019
2019
Identification of prognostic biomarkers for patients withhepatocellular carcinoma after hepatectomy
Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of… (More)
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2018
2018
Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects
Ritodrine is a commonly used tocolytic to prevent preterm labour. However, it can cause unexpected serious adverse reactions… (More)
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2015
2015
MafG, A Novel Target of FXR that Regulates Bile Acid Homeostasis.
Bile acids, the major products of hepatic cholesterol catabolism, are indispensable for lipid absorption and cholesterol… (More)
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2014
2014
UPAYA MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR MATEMATIKA DENGAN STRATEGI THINK TALK WRITE (TTW) SISWA KELAS VIIIB SMP NEGERI 1 BULUKERTO WONOGIRITAHUN PELAJARAN 2013/2014
 
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2013
2013
Single nucleotide polymorphism rs3732860 in the 3'-untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese.
BACKGROUND AND AIMS Gallstone disease (GD) is a common disease of multigenetic origin; however, the major susceptibility loci for… (More)
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2011
2011
Comparison of receptors and enzymes regulating cholesterol levels in liver between SHR/NDmcr-cp rats and normotensive Wistar Kyoto rats at ten weeks of age.
The spontaneously hypertensive rat (SHR)/NDmcr-cp (SHR-cp), which is a metabolic syndrome model rat, was reported to show… (More)
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2006
2006
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.
As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1-/-) fail to produce cholic acid (CA… (More)
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Highly Cited
2006
Highly Cited
2006
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver. Mice lacking… (More)
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2006
2006
Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit.
An intercross between C57BL/6J and CASA/Rk mice was used to study the genetics of biliary bile acid composition. In parental… (More)
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2005
2005
Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile.
OBJECTIVE In humans, two primary bile acids are synthesized: cholic acid (CA) and chenodeoxycholic acid (CDCA), the first and… (More)
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