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CYP8B1 gene
Known as:
cytochrome P450 family 8 subfamily B member 1
, CYP8B1
, STEROL 12-ALPHA-HYDROXYLASE
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This gene plays a role in steroid metabolism and regulation of cholesterol solubility.
National Institutes of Health
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Related topics
Related topics
8 relations
CYP8B1 protein, human
CYP8B1 wt Allele
Iron Chelation
Metabolic Detoxication, Drug
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with…
P. Petrov
,
L. Fernández-Murga
,
+4 authors
R. Jover
Archives of Toxicology
2020
Corpus ID: 209516782
Anabolic–androgenic steroids are testosterone derivatives, used by body-builders to increase muscle mass. Epistane (EPI) is an…
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2019
2019
A Possible Mechanism of Metformin in Improving Insulin Resistance in Diabetic Rat Models
Mengsiyu Li
,
Xiaowen Hu
,
Yeqiu Xu
,
Xiaolin Hu
,
Chunxue Zhang
,
S. Pang
International journal of endocrinology
2019
Corpus ID: 208060250
Background Type 2 diabetes has become one of the most common diseases worldwide, causing a serious social burden. As a first-line…
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2019
2019
Signatures of relaxed selection in the CYP8B1 gene of birds and mammals
Sagar Sharad Shinde
,
Lokdeep Teekas
,
Sandhya Sharma
,
N. Vijay
bioRxiv
2019
Corpus ID: 199380339
The CYP8B1 gene is known to catalyse reactions that determine the ratio of primary bile salts and the loss of this gene has…
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2019
2019
Identification of prognostic biomarkers for patients withhepatocellular carcinoma after hepatectomy
Xiang-kun Wang
,
Xiwen Liao
,
+12 authors
T. Peng
Oncology reports
2019
Corpus ID: 58549113
Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of…
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2018
2018
Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects
H. Seo
,
E. Kwon
,
+6 authors
Young Ju Kim
BMC Medical Genomics
2018
Corpus ID: 10744127
BackgroundRitodrine is a commonly used tocolytic to prevent preterm labour. However, it can cause unexpected serious adverse…
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2013
2013
Single nucleotide polymorphism rs3732860 in the 3′‐untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese
Jian Qin
,
T. Han
,
+10 authors
Sheng-dao Zhang
Journal of gastroenterology and hepatology
2013
Corpus ID: 43376794
Gallstone disease (GD) is a common disease of multigenetic origin; however, the major susceptibility loci for GD in human…
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2007
2007
Superactivity and dual reactivity of the system N-iodosuccinimide-H2SO4 in the iodination of deactivated arenes
V. K. Chaikovskii
,
V. Filimonov
,
V. Skorokhodov
,
V. D. Ogorodnikov
2007
Corpus ID: 98269288
Dissolution of N-iodosuccinimide in sulfuric acid gives rise to electrophilic iodine-containing species which are capable of…
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Highly Cited
2006
Highly Cited
2006
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Y. Inoue
,
A. Yu
,
+8 authors
F. Gonzalez
Journal of lipid research
2006
Corpus ID: 24561551
Hepatocyte nuclear factor 4alpha (HNF4alpha) regulates many genes that are preferentially expressed in liver. Mice lacking…
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Highly Cited
2006
Highly Cited
2006
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice Published, JLR Papers in Press, November 1, 2005.
J. Wang
,
C. Einarsson
,
+4 authors
G. Eggertsen
Journal of Lipid Research
2006
Corpus ID: 1266346
As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1−/−) fail to produce cholic acid (CA…
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2006
2006
Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprits⃞ Published, JLR Papers in Press, June 8, 2006.
E. Sehayek
,
L. Hagey
,
+6 authors
J. Breslow
Journal of Lipid Research
2006
Corpus ID: 19992794
An intercross between C57BL/6J and CASA/Rk mice was used to study the genetics of biliary bile acid composition. In parental…
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