CYP46A1 cholesterol 24-hydroxylase activity

Known as: CYP46A1 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2017
012320042017

Papers overview

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2016
2016
Huntington's disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin… (More)
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2015
2015
Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The amyloid component and altered cholesterol… (More)
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2012
2012
The deregulation of brain cholesterol metabolism is typical in acute neuronal injury (such as stroke, brain trauma and epileptic… (More)
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2011
2011
Cytochrome P450 enzymes (CYP or P450) 46A1 and 27A1 play important roles in cholesterol elimination from the brain and retina… (More)
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2010
2010
The major mechanism of brain cholesterol elimination is the conversion of cholesterol into 24S-hydroxycholesterol by CYP46A1, a… (More)
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Highly Cited
2009
Highly Cited
2009
Cytochrome P450 (P450) enzymes and ATP-binding cassette (ABC) transporters modulate the transport and metabolism of both… (More)
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2009
2009
OBJECTIVES We previously found that the polymorphisms of cholesterol 24-hydroxylase (CYP46A1) gene were associated with the risk… (More)
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2008
2008
In humans, the brain represents only about 2% of the body's mass but contains about one-quarter of the body's free cholesterol… (More)
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2005
2005
Recent epidemiological, biological and genetic data indicate a relationship between cholesterol and Alzheimer's disease (AD… (More)
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2004
2004
alpha-Methylacyl-CoA racemase (Amacr) deficiency in humans leads to sensory motor neuronal and liver abnormalities. The disorder… (More)
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