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CYP46A1 cholesterol 24-hydroxylase activity

Known as: CYP46A1 
 
National Institutes of Health

Papers overview

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2015
2015
Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The amyloid component and altered cholesterol… Expand
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Highly Cited
2010
Highly Cited
2010
The development of Alzheimer's disease (AD) is closely connected with cholesterol metabolism. Cholesterol increases the… Expand
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2010
2010
Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain and thereby controls… Expand
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Highly Cited
2010
Highly Cited
2010
  • Jun Lu, Dong-Mei Wu, +6 authors Yong-Jian Wang
  • The Journal of pathology
  • 2010
  • Corpus ID: 206324704
It is known that a high-cholesterol diet induces oxidative stress, inflammatory response, and beta-amyloid (Abeta) accumulation… Expand
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2008
2008
Brain defective cholesterol homeostasis has been associated with neurologic diseases, such as Alzheimer's and Huntington's… Expand
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2007
2007
Increasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in… Expand
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Highly Cited
2006
Highly Cited
2006
Mammalian CNS contains a disproportionally large and remarkably stable pool of cholesterol. Despite an efficient recycling there… Expand
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Review
2006
Review
2006
  • Irina A. Pikuleva
  • Drug metabolism and disposition: the biological…
  • 2006
  • Corpus ID: 304953
By catalyzing the first steps in different pathways of cholesterol degradation, cytochromes P450 (P450s) 7A1, 27A1, 11A1, and… Expand
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Highly Cited
2004
Highly Cited
2004
Cholesterol is eliminated from neurons by oxidization, which generates oxysterols. Cholesterol oxidation is mediated by the… Expand
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2004
2004
alpha-Methylacyl-CoA racemase (Amacr) deficiency in humans leads to sensory motor neuronal and liver abnormalities. The disorder… Expand
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