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CYP46A1 cholesterol 24-hydroxylase activity
Known as:
CYP46A1
National Institutes of Health
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2 relations
Cytochrome P450 46A1
cholesterol 24-hydroxylase activity
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
P04.44 Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
Mingzhi Han
,
Shuai Wang
,
Jian Wang
,
Xia Li
,
R. Bjerkvig
Neuro-Oncology
2018
Corpus ID: 81425448
2016
2016
Flux of cholesterol, oxysterols and plant sterols across the blood-brain barrier and metabolic consequences
A. Saeed
2016
Corpus ID: 44113961
Brain is the cholesterol-richest organ and contains one fourth of the total body cholesterol. The majority of brain cholesterol…
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2015
2015
Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676)
Yoshikazu Uto
Expert Opinion on Therapeutic Patents
2015
Corpus ID: 31327110
A series of imidazo[1,2-a]pyridine analogs that effectively inhibit cholesterol 24-hydroxylase (CYP46A1) was reported in…
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2015
2015
Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
C. Fourgeux
,
L. Martine
,
S. Gambert-Nicot
,
A. Bron
,
C. Creuzot-Garcher
,
L. Bretillon
2015
Corpus ID: 52484801
The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic…
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2013
2013
Stimulation of cerebral cholesterol turnover 1 Pharmacologic stimulation of cytochrome P 450 46 A 1 and cerebral cholesterol turnover in mice
Natalia Mast
,
Yong Li
,
M. Linger
,
M. Clark
,
J. Wiseman
,
I. Pikuleva
2013
Corpus ID: 207857188
Cytochrome P450 46A1 (CYP46A1) is a brainspecific cholesterol 24-hydroxylase responsible for the majority of cholesterol…
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2012
2012
Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells
I. Milagre
,
M. Olin
,
+5 authors
E. Rodrigues
Neurochemistry International
2012
Corpus ID: 12750855
Review
2011
Review
2011
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.
C. Fourgeux
,
A. Bron
,
N. Acar
,
C. Creuzot-Garcher
,
L. Bretillon
Chemistry and Physics of Lipids
2011
Corpus ID: 24576155
2009
2009
Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.
W. Liao
,
N. Dodder
,
Natalia Mast
,
I. Pikuleva
,
I. Turko
Biochemistry
2009
Corpus ID: 25476705
Cytochrome P450 46A1 (CYP46A1) is a key enzyme responsible for cholesterol elimination from the brain. This P450 can interact…
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Review
2009
Review
2009
[Cytochrome P450 isoenzymes in metabolism of endo- and exogenic compounds].
A. Wiśniewska
,
Z. Mazerska
Postepy biochemii
2009
Corpus ID: 36763990
Cytochrome P450 enzymes (CYPs) belong to hemeproteins found in all living organisms. In eucaryotic cells they are responsible for…
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2007
2007
Statin-like drugs for the treatment of brain cholesterol loss in Alzheimer's disease.
Elisa Biondi
Current Drug Safety
2007
Corpus ID: 29379987
Aging is one of the most significant risk factors for neurological disorders including Alzheimer's Disease (late-onset AD and…
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