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CYP46A1 cholesterol 24-hydroxylase activity

Known as: CYP46A1 
 
National Institutes of Health

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Cytochrome P450 46A1cholesterol 24-hydroxylase activity

Papers overview

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2015
2015
Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.
Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The amyloid component and altered cholesterol… Expand
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Highly Cited
2010
Highly Cited
2010
Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.
The development of Alzheimer's disease (AD) is closely connected with cholesterol metabolism. Cholesterol increases the… Expand
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2010
2010
Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain and thereby controls… Expand
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Highly Cited
2010
Highly Cited
2010
Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.
  • Jun Lu, Dong-Mei Wu, +6 authors Yong-Jian Wang
  • The Journal of pathology
  • 2010
    • Corpus ID: 206324704
It is known that a high-cholesterol diet induces oxidative stress, inflammatory response, and beta-amyloid (Abeta) accumulation… Expand
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2008
2008
Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.
Brain defective cholesterol homeostasis has been associated with neurologic diseases, such as Alzheimer's and Huntington's… Expand
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2007
2007
Cholesterol-24S-hydroxylase (CYP46A1) Is Specifically Expressed in Neurons of the Neural Retina
Increasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in… Expand
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Highly Cited
2006
Highly Cited
2006
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
Mammalian CNS contains a disproportionally large and remarkably stable pool of cholesterol. Despite an efficient recycling there… Expand
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Review
2006
Review
2006
Cholesterol-metabolizing cytochromes P450.
  • Irina A. Pikuleva
  • Drug metabolism and disposition: the biological…
  • 2006
    • Corpus ID: 304953
By catalyzing the first steps in different pathways of cholesterol degradation, cytochromes P450 (P450s) 7A1, 27A1, 11A1, and… Expand
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Highly Cited
2004
Highly Cited
2004
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Cholesterol is eliminated from neurons by oxidization, which generates oxysterols. Cholesterol oxidation is mediated by the… Expand
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2004
2004
A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.
alpha-Methylacyl-CoA racemase (Amacr) deficiency in humans leads to sensory motor neuronal and liver abnormalities. The disorder… Expand
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