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CYP46A1 cholesterol 24-hydroxylase activity

Known as: CYP46A1 
National Institutes of Health

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Cytochrome P450 46A1cholesterol 24-hydroxylase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
P04.44 Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
2016
2016
Flux of cholesterol, oxysterols and plant sterols across the blood-brain barrier and metabolic consequences
Brain is the cholesterol-richest organ and contains one fourth of the total body cholesterol. The majority of brain cholesterol… 
2015
2015
Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676)
A series of imidazo[1,2-a]pyridine analogs that effectively inhibit cholesterol 24-hydroxylase (CYP46A1) was reported in… 
2015
2015
Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic… 
2013
2013
Stimulation of cerebral cholesterol turnover 1 Pharmacologic stimulation of cytochrome P 450 46 A 1 and cerebral cholesterol turnover in mice
Cytochrome P450 46A1 (CYP46A1) is a brainspecific cholesterol 24-hydroxylase responsible for the majority of cholesterol… 
2012
2012
Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells
Review
2011
Review
2011
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.
2009
2009
Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.
Cytochrome P450 46A1 (CYP46A1) is a key enzyme responsible for cholesterol elimination from the brain. This P450 can interact… 
Review
2009
Review
2009
[Cytochrome P450 isoenzymes in metabolism of endo- and exogenic compounds].
Cytochrome P450 enzymes (CYPs) belong to hemeproteins found in all living organisms. In eucaryotic cells they are responsible for… 
2007
2007
Statin-like drugs for the treatment of brain cholesterol loss in Alzheimer's disease.
Aging is one of the most significant risk factors for neurological disorders including Alzheimer's Disease (late-onset AD and… 
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