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Cytochrome P450 46A1

Known as: CYP46A1 
National Institutes of Health

Related topics

Related topics

3 relations
CYP46A1 cholesterol 24-hydroxylase activityCYP46A1 gene

Broader (1)

cholesterol 24-hydroxylase

Papers overview

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2018
2018
I13 Striatal regulation of cholesterol metabolism by CYP46A1 is associated with multiple benefits in huntington’s disease knock-in mice models
Background Recently, altered brain cholesterol homeostasis has been implicated in Huntington’s disease (HD) pathogenesis. Our… 
2013
2013
Stimulation of cerebral cholesterol turnover 1 Pharmacologic stimulation of cytochrome P 450 46 A 1 and cerebral cholesterol turnover in mice
Cytochrome P450 46A1 (CYP46A1) is a brainspecific cholesterol 24-hydroxylase responsible for the majority of cholesterol… 
2012
2012
Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter
J. Neurochem. (2012) 120, 220–229. 
2012
2012
Combined Deficiency In Cholesterol-metabolizing Cyp27A1 And Cyp46A1 Leads To Neovascularization And Lipids Accumulation In Mouse Retina
2011
2011
Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination.
The major mechanism of brain cholesterol elimination is the conversion of cholesterol into 24S-hydroxycholesterol by CYP46A1, a… 
2011
2011
Análisis genéticos de polimorfismos en los genes CYP46A1, OGG1, CYP17A1 y CYP1A1 en pacientes con deterioro cognitivo leve tipo amnésico (aDCL) y enfermedad de Alzheimer (EA) portadores del alelo…
EnglishThe aim of this study is to examine the influence of the functional polymorphisms allocated in 24S-hydroxylase (CYP46A1… 
2010
2010
24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration
Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol… 
2009
2009
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase.
2009
2009
Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.
Cytochrome P450 46A1 (CYP46A1) is a key enzyme responsible for cholesterol elimination from the brain. This P450 can interact… 
2007
2007
Repression of the human CYP46A1 promoter by retinoic acid
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