Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.

@article{Milagre2012MarkedCI,
  title={Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.},
  author={In{\^e}s Milagre and Maria Olin and Maria Jo{\~a}o Nunes and M A Koyota Moutinho and Anita L{\"o}vgren-Sandblom and Maria Jo{\~a}o Gama and Ingemar Bj{\"o}rkhem and Elsa Rodrigues},
  journal={Neurochemistry international},
  year={2012},
  volume={60 2},
  pages={192-8}
}
Cholesterol metabolism in the brain is distinct from that in other tissues due to the fact that cholesterol itself is unable to pass across the blood-brain barrier. Elimination of brain cholesterol is mainly dependent on a neuronal-specific cytochrome P450, CYP46A1, catalyzing the conversion of cholesterol into 24(S)-hydroxycholesterol (24OHC), which is able to pass the blood-brain barrier. A suitable model for studying this elimination from human neuronal cells has not been described… CONTINUE READING