Skip to search formSkip to main contentSkip to account menu

CUL2 gene

Known as: CUL2, CULLIN 2, Cullin 2 Gene 
This gene is involved in protein degradation and the negative regulation of cell proliferation.
National Institutes of Health

Related topics

Related topics

3 relations
Cullin 2 ProteinProtein Degradation, RegulatoryUbiquitination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics.
2017
2017
Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5
ABSTRACT Members of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3 [A3]) family of DNA cytidine… 
2014
2014
Cellular Requirements for Bovine Immunodeficiency Virus Vif-Mediated Inactivation of Bovine APOBEC3 Proteins
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) viral infectivity factor (Vif) form… 
2013
2013
Abstract 330A: Differential expression of angiogenic genes in invasive high grade serous ovarian carcinomas.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Our objective is to establish quantifiable and… 
2011
2011
Abstract 3980: Hypoxia-induced microRNA-424 targets CUL2 to stabilize HIF-α isoforms and promotes angiogenesis
Chronic hypoxia, a hallmark of many tumors, is associated with angiogenesis and tumor progression. Adaptive changes to oxygen… 
2010
2010
No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer
AbstractpVHL is the central component of an ubiquitin ligase complex that targets hypoxia-inducible factor 1α (HIF-1α) for… 
2009
2009
Mutational analysis of hypoxia‐related genes HIF1α and CUL2 in common human cancers
Park SW, Chung NG, Hur SY, Kim HS, Yoo NJ, Lee SH. Mutational analysis of hypoxia‐related genes HIF1α and CUL2 in common human… 
2008
2008
The COP9/Signalosome Increases the Efficiency of von Hippel-Lindau Protein Ubiquitin Ligase-mediated Hypoxia-inducible Factor-α Ubiquitination*
Oxygen-dependent ubiquitination of the α-subunit of hypoxia-inducible factor (HIF-α) by the (von Hippel-Lindau protein)-Elongin B… 
2006
2006
Association of the HPV-16 E7 oncoprotein with the cullin 2 ubiquitin ligase complex.
Proc Amer Assoc Cancer Res, Volume 47, 2006 5644 Human papillomaviruses (HPVs) are small DNA viruses that exhibit a tropism… 
2005
2005
Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II
The ubiquitin-mediated protein degradation system is involved in a wide variety of cellular functions. The RING-H2 finger protein… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)