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Species-Specific Exclusion of APOBEC3G from HIV-1 Virions by Vif
The HIV-1 accessory protein Vif (virion infectivity factor) is required for the production of infectious virions by CD4(+) lymphocytes. Vif facilitates particle infectivity by blocking the inhibitoryExpand
APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition*
The human cytidine deaminase family APOBEC3 represents a novel group of proteins in the field of innate defense mechanisms that has been shown to be active against a variety of retroviruses. Here weExpand
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Clearance of Chronic Virus The family of mRNA-editing enzymes, APOBEC, restricts hepatitis B virus (HBV) replication. Lucifora et al. (p. 1221, published online 20 February; see the Perspective byExpand
Functions, structure, and read-through alternative splicing of feline APOBEC3 genes
BackgroundOver the past years a variety of host restriction genes have been identified in human and mammals that modulate retrovirus infectivity, replication, assembly, and/or cross-speciesExpand
A dominant block to HIV-1 replication at reverse transcription in simian cells
Although nonhuman primates are genetically close to humans, their T cells do not support productive replication of HIV-1. In contrast, HIV-1 replicates in activated human CD4+ T cells, monocytes, andExpand
The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein
Genome hypermutation of different orthoretroviruses by cellular cytidine deaminases of the APOBEC3 family during reverse transcription has recently been observed. Lentiviruses like HIV-1 haveExpand
APOBEC3A, APOBEC3B, and APOBEC3H Haplotype 2 Restrict Human T-Lymphotropic Virus Type 1
ABSTRACT The human APOBEC3 family consists of seven cytidine deaminases (A3A to A3H), some of which display potent antiretroviral activity against HIV-1 and other retroviruses. Studies that analyzedExpand
Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins
Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins Rebecca S. LaRue, Valgerdur Andresdottir, Yannick Blanchard, Silvestro G. Conticello, David Derse, Michael Emerman, Warner C. Greene,Expand
An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals
BackgroundThe APOBEC3 (A3) genes play a key role in innate antiviral defense in mammals by introducing directed mutations in the DNA. The human genome encodes for seven A3 genes, with multiple spliceExpand
Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells
HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor. This block reduces the usefulness of HIV-1-based lentiviralExpand