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CS-514
Known as:
CS 514
, CS514
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Pravastatin
Pravastatin Sodium
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials
C. Schooling
,
S. A. Au Yeung
,
G. Freeman
,
B. Cowling
BMC Medicine
2013
Corpus ID: 8105295
BackgroundStatins are extensively used for cardiovascular disease prevention. Statins reduce mortality rates more than other…
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1993
1993
Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme…
L. Cohen
,
A. V. van Vliet
,
L. Roodenburg
,
L. M. Jansen
,
M. Griffioen
Biochemical Pharmacology
1993
Corpus ID: 38759272
Highly Cited
1992
Highly Cited
1992
Inhibition of cultured vascular smooth muscle cell migration by simvastatin (MK-733).
Y. Hidaka
,
T. Eda
,
M. Yonemoto
,
T. Kamei
Atherosclerosis
1992
Corpus ID: 40347889
Highly Cited
1991
Highly Cited
1991
A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme…
N. Serizawa
,
T. Matsuoka
Biochimica et Biophysica Acta
1991
Corpus ID: 20075706
Highly Cited
1990
Highly Cited
1990
Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia.
N. Hoogerbrugge-vd Linden
,
F. W. de Rooy
,
H. Jansen
,
M. van Blankenstein
Gut
1990
Corpus ID: 15247543
Nine patients with heterozygous familial hypercholesterolaemia were treated for eight weeks with either 40 mg pravastatin or…
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1990
1990
Effect of pravastatin sodium, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on very-low-density lipoprotein composition and kinetics in hyperlipidemia associated with…
T. Hirano
,
F. Komuro
,
S. Furukawa
,
S. Nagano
,
T. Takahashi
Metabolism: Clinical and Experimental
1990
Corpus ID: 1909590
Highly Cited
1989
Highly Cited
1989
Purification and characterization of cytochrome P-450sca from Streptomyces carbophilus. ML-236B (compactin) induces a cytochrome P-450sca in Streptomyces carbophilus that hydroxylates ML-236B to…
T. Matsuoka
,
S. Miyakoshi
,
K. Tanzawa
,
K. Nakahara
,
M. Hosobuchi
,
N. Serizawa
European Journal of Biochemistry
1989
Corpus ID: 24140511
Pravastatin sodium (CS-514) is a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme in…
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Highly Cited
1987
Highly Cited
1987
The effect of CS-514 on serum lipids and apolipoproteins in hypercholesterolemic subjects.
N. Nakaya
,
Y. Homma
,
H. Tamachi
,
H. Shigematsu
,
Y. Hata
,
Y. Goto
JAMA
1987
Corpus ID: 36089489
CS-514 is a metabolic product of compactin and has a potent cholesterol-lowering effect in vitro and in animal studies by…
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Highly Cited
1987
Highly Cited
1987
New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.
J. Tobert
Circulation
1987
Corpus ID: 23704820
HMG-CoA reductase catalyzes the conversion of hydroxymethylglutarate to mevalonate, an important early rate-limiting step in the…
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Highly Cited
1986
Highly Cited
1986
CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species.
Y. Tsujita
,
M. Kuroda
,
+7 authors
Y. Watanabe
Biochimica et Biophysica Acta
1986
Corpus ID: 21862444
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