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CS-514

Known as: CS 514, CS514 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PravastatinPravastatin Sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials
BackgroundStatins are extensively used for cardiovascular disease prevention. Statins reduce mortality rates more than other… 
1993
1993
Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme…
Highly Cited
1992
Highly Cited
1992
Inhibition of cultured vascular smooth muscle cell migration by simvastatin (MK-733).
Highly Cited
1991
Highly Cited
1991
A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme…
Highly Cited
1990
Highly Cited
1990
Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia.
Nine patients with heterozygous familial hypercholesterolaemia were treated for eight weeks with either 40 mg pravastatin or… 
1990
1990
Effect of pravastatin sodium, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on very-low-density lipoprotein composition and kinetics in hyperlipidemia associated with…
Highly Cited
1989
Highly Cited
1989
Purification and characterization of cytochrome P-450sca from Streptomyces carbophilus. ML-236B (compactin) induces a cytochrome P-450sca in Streptomyces carbophilus that hydroxylates ML-236B to…
Pravastatin sodium (CS-514) is a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme in… 
Highly Cited
1987
Highly Cited
1987
The effect of CS-514 on serum lipids and apolipoproteins in hypercholesterolemic subjects.
CS-514 is a metabolic product of compactin and has a potent cholesterol-lowering effect in vitro and in animal studies by… 
Highly Cited
1987
Highly Cited
1987
New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.
HMG-CoA reductase catalyzes the conversion of hydroxymethylglutarate to mevalonate, an important early rate-limiting step in the… 
Highly Cited
1986
Highly Cited
1986
CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species.
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