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CP 105696

Known as: CP 105,696, CP-105,696, CP105,696 
National Institutes of Health

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2 relations

Broader (2)

BenzopyransCarboxylic Acids

Papers overview

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2016
2016
Pharmacokinetics of the potent LTB4 Inhibitor, CP-105696, in Male and Female Mice.
Leukotriene B4 (LTB4) is a proinflammatory mediator important in the progression of a number of inflammatory diseases… 
2011
2011
Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells: Effects on calcium transients, adhesive events and mediator release.
2006
2006
Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis.
PURPOSE To investigate the role of leukotriene B4 (LTB4) and its receptor BLT1 in the pathogenesis of mouse uveitis. METHODS… 
2003
2003
IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4.
IL-18 expression and functional activity have been associated with a range of autoimmune diseases. However, the precise mechanism… 
2003
2003
Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist‐induced activation and retardation of apoptosis
Since most inflammatory mediators that stimulate granulocyte responsiveness also delay apoptosis, it is often assumed that… 
2003
2003
Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement
We report in human neutrophils (PMN) that phospholipase D (PLD) was stimulated by micromolar concentrations of arachidonic acid… 
Highly Cited
2003
Highly Cited
2003
The critical role of leukotriene B4 in antigen‐induced mechanical hyperalgesia in immunised rats
We investigated the mediators responsible for mechanical hypersensitivity induced by antigen challenge in rats immunised with… 
2003
2003
Gut-derived leukotriene B4 following hemorrhagic shock is a pivotal mediator of neutrophil priming
2002
2002
Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules.
1. Protein synthesis dependency and the role of endogenously generated platelet activating factor (PAF) and leukotriene B(4) (LTB… 
2002
2002
The role of migrating leukocytes in IL-1 beta-induced up-regulation of kinin B(1) receptors in rats.
1. The present study examines the role of migrating leukocytes in the ability of IL-1 beta to induce the functional up-regulation… 
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