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A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.
- T. Cunha, W. Verri, J. Silva, S. Poole, F. Cunha, S. Ferreira
- Chemistry, MedicineProceedings of the National Academy of Sciences…
- 1 February 2005
Results extend to mice the concept that the release of primary mediators responsible for hypernociception is preceded by a cascade of cytokines.
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
The delineation of the role of TNF alpha,IL-1 beta, IL-6 and IL-8 in the development of inflammatory hyperalgesia taken together with the finding that the production of these cytokines is inhibited by steroidal anti-inflammatory drugs provides a mechanism of action for these drugs in the treatment ofinflammatory hyperalGESia.
A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.
- S. Ferreira
- Chemistry, MedicineBritish journal of pharmacology and chemotherapy
- 1 February 1965
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.
Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
- W. Verri, T. Cunha, C. Parada, S. Poole, F. Cunha, S. Ferreira
- MedicinePharmacology & therapeutics
- 1 October 2006
The evidence suggesting pro- and anti-inflammatory cytokines and chemokines are potential targets to develop novel drugs and therapies for the treatment of pain is emphasized, emphasizing the importance of the direct and indirect actions of cytokine actions in inflammatory and neuropathic hypernociception.
Heme oxygenase/carbon monoxide‐biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation
- A. Freitas, J. Alves-Filho, +4 authors F. Q. Cunha
- Chemistry, MedicineBritish journal of pharmacology
- 1 October 2006
The role of HO and its metabolites, carbon monoxide (CO) and biliverdin (BVD), in leukocyte rolling, adhesion and neutrophil migration during inflammatory processes is addressed.
Prostaglandins, aspirin-like drugs and analgesia.
- S. Ferreira
- MedicineNature: New biology
- 13 December 1972
Compared the pain producing activity of fatty acid hydroperoxides with that of high concentrations of acetylcholine, bradykinin, histamine and PGE1 on intradermal injection in man, the intensity of the pain induced was greater than that induced by the other agonists but for all except P GE1 the pain was transitory.
Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice.
The results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleucin 8 by resident peritoneal macrophages and mast cells.
Prostaglandins: Their Disappearance from and Release into the Circulation
The liver and lungs provide an efficient protective mechanism to remove almost all the prostaglandin before it reaches the arterial circulation.
Interleukin‐8 as a mediator of sympathetic pain
- F. Cunha, B. B. Lorenzetti, S. Poole, S. Ferreira
- MedicineBritish journal of pharmacology
- 1 November 1991
IL‐8 is the first endogenous mediator to be identified as evoking hyperalgesia involving the sympathetic nervous system, and a new biological activity of IL-8 is described, namely the capacity to evoke hyperAlgesia by a prostaglandin‐independent mechanism.