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A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.
The hypernociceptive effects of cytokines [TNF-alpha, keratinocyte-derived chemokine (KC), and IL-1beta] and their participation in carrageenan (Cg)-induced inflammatory hypernociception in mice wereExpand
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The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
1. The hyperalgesic activities in rats of interleukin-1 beta (IL-1 beta), IL-6, IL-8, tumour necrosis factor alpha (TNF alpha) and carrageenin were investigated. 2. IL-6 activated the previouslyExpand
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Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue
Interleukin-1 (IL-1) describes two inflammatory proteins1, IL-1α and IL-1β, produced by activated macrophages and other cell types2 and encoded by two genes. Their amino acid sequences have only 26%Expand
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Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice.
Intraperitoneal administration of zymosan and acetic acid induced a dose-dependent nociceptive writhing response in mice. Lavage of the peritoneal cavities with saline reduced the number of totalExpand
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Morphine peripheral analgesia depends on activation of the PI3Kγ/AKT/nNOS/NO/KATP signaling pathway
Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheralExpand
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  • S. Ferreira
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
  • 1 February 1965
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Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
Pain is one of the classical signs of the inflammatory process in which sensitization of the nociceptors is the common denominator. This sensitization causes hyperalgesia or allodynia in humans,Expand
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Heme oxygenase/carbon monoxide‐biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation
Heme oxygenase (HO) activity is known to down‐regulate inflammatory events. Here, we address the role of HO and its metabolites, carbon monoxide (CO) and biliverdin (BVD), in leukocyte rolling,Expand
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Central and peripheral antialgesic action of aspirin-like drugs.
The peripheral and central effects of some non-steroid anti-inflammatory drugs, aspirin, indomethacin, paracetamol and phenacetin were studied by comparing their intraplantar andExpand
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