A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.
- T. Cunha, W. Verri, J. Silva, S. Poole, F. Cunha, S. Ferreira
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 February 2005
Results extend to mice the concept that the release of primary mediators responsible for hypernociception is preceded by a cascade of cytokines.
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
- F. Cunha, S. Poole, B. B. Lorenzetti, S. Ferreira
- Medicine, BiologyBritish Journal of Pharmacology
- 1992
The delineation of the role of TNF alpha,IL-1 beta, IL-6 and IL-8 in the development of inflammatory hyperalgesia taken together with the finding that the production of these cytokines is inhibited by steroidal anti-inflammatory drugs provides a mechanism of action for these drugs in the treatment ofinflammatory hyperalGESia.
A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.
- S. Ferreira
- Biology, ChemistryBritish Journal of Pharmacology and Chemotherapy
- 1 February 1965
While determining whether dimercaprol could potentiate in situ the slowly reacting substances released by the venom of Bothrops when acting on the guinea-pig isolated ileum, it was found that the venom itself had a strong potentiating action upon the concentrations elicited by bradykinin.
Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice.
- R. Ribeiro, M. L. Vale, F. Cunha
- Biology, MedicineEuropean Journal of Pharmacology
- 3 November 2000
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.
- S. Ferreira, D. Bartelt, L. J. Greene
- BiologyBiochemistry
- 23 June 1970
Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
- J. Alves-Filho, A. Freitas, F. Cunha
- Biology, MedicineProceedings of the National Academy of Sciences
- 10 March 2009
The findings identify an unexpected detrimental role of TLR2 in polymicrobial sepsis and suggest that inhibition ofTLR2 signaling may improve survival from septicaemia.
Heme oxygenase/carbon monoxide‐biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation
- A. Freitas, J. Alves-Filho, F. Cunha
- BiologyBritish Journal of Pharmacology
- 1 October 2006
The role of HO and its metabolites, carbon monoxide (CO) and biliverdin (BVD), in leukocyte rolling, adhesion and neutrophil migration during inflammatory processes is addressed.
Fractalkine mediates inflammatory pain through activation of satellite glial cells
- G. Souza, J. Talbot, C. Lotufo, F. Cunha, T. Cunha, S. Ferreira
- Biology, MedicineProceedings of the National Academy of Sciences
- 17 June 2013
Results suggest that, during peripheral inflammation, fractalkine is released in the DRG and contributes to the genesis of inflammatory hypernociception, and the inhibition of fractalksine/CX3CR1 signaling in SGCs may serve as a target to control inflammatory pain.
Prostaglandins, aspirin-like drugs and analgesia.
- S. Ferreira
- BiologyNature: New biology
- 13 December 1972
Compared the pain producing activity of fatty acid hydroperoxides with that of high concentrations of acetylcholine, bradykinin, histamine and PGE1 on intradermal injection in man, the intensity of the pain induced was greater than that induced by the other agonists but for all except P GE1 the pain was transitory.
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