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- Publications
- Influence
A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.
- T. Cunha, W. A. Verri, J. Silva, S. Poole, F. Cunha, S. Ferreira
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 2005
The hypernociceptive effects of cytokines [TNF-alpha, keratinocyte-derived chemokine (KC), and IL-1beta] and their participation in carrageenan (Cg)-induced inflammatory hypernociception in mice were… Expand
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
- F. Cunha, S. Poole, B. B. Lorenzetti, S. Ferreira
- Medicine
- British journal of pharmacology
- 1992
1. The hyperalgesic activities in rats of interleukin-1 beta (IL-1 beta), IL-6, IL-8, tumour necrosis factor alpha (TNF alpha) and carrageenin were investigated. 2. IL-6 activated the previously… Expand
Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue
- S. Ferreira, B. B. Lorenzetti, A. Bristow, S. Poole
- Chemistry, Medicine
- Nature
- 1 August 1988
Interleukin-1 (IL-1) describes two inflammatory proteins1, IL-1α and IL-1β, produced by activated macrophages and other cell types2 and encoded by two genes. Their amino acid sequences have only 26%… Expand
Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice.
- R. Ribeiro, M. L. Vale, +4 authors F. Cunha
- Medicine
- European journal of pharmacology
- 3 November 2000
Intraperitoneal administration of zymosan and acetic acid induced a dose-dependent nociceptive writhing response in mice. Lavage of the peritoneal cavities with saline reduced the number of total… Expand
Morphine peripheral analgesia depends on activation of the PI3Kγ/AKT/nNOS/NO/KATP signaling pathway
- T. M. Cunha, D. Roman-Campos, +14 authors S. Ferreira
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 10 February 2010
Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheral… Expand
A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.
- S. Ferreira
- Chemistry, Medicine
- British journal of pharmacology and chemotherapy
- 1 February 1965
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.
- S. Ferreira, D. Bartelt, L. Greene
- Chemistry, Medicine
- Biochemistry
- 23 June 1970
Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
- W. A. Verri, T. M. Cunha, C. Parada, S. Poole, F. Cunha, S. Ferreira
- Medicine
- Pharmacology & therapeutics
- 1 October 2006
Pain is one of the classical signs of the inflammatory process in which sensitization of the nociceptors is the common denominator. This sensitization causes hyperalgesia or allodynia in humans,… Expand
Heme oxygenase/carbon monoxide‐biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation
- A. Freitas, J. C. Alves-Filho, +4 authors F. Cunha
- Chemistry, Medicine
- British journal of pharmacology
- 1 October 2006
Heme oxygenase (HO) activity is known to down‐regulate inflammatory events. Here, we address the role of HO and its metabolites, carbon monoxide (CO) and biliverdin (BVD), in leukocyte rolling,… Expand
Central and peripheral antialgesic action of aspirin-like drugs.
- S. Ferreira, B. B. Lorenzetti, F. M. Corrêa
- Chemistry, Medicine
- European journal of pharmacology
- 15 December 1978
The peripheral and central effects of some non-steroid anti-inflammatory drugs, aspirin, indomethacin, paracetamol and phenacetin were studied by comparing their intraplantar and… Expand