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Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐1 receptor antagonist
The effect of IL‐1ra on response to intraplantar (i.pl.) injection of LPS, carrageenin, bradykinin, TNFα, IL‐1β, IL‐8, PGE2 and dopamine was investigated in a model of mechanical hyperalgesia inExpand
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Diabetic neuropathic pain: Physiopathology and treatment.
Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which affects over 90% of the diabetic patients. Although pain is one of the main symptoms of diabetic neuropathy, itsExpand
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B vitamins alleviate indices of neuropathic pain in diabetic rats.
There are sporadic reports that assorted combinations of B vitamins can alleviate pain in diabetic patients, but there is neither agreement on the relative efficacy of individual B vitamins norExpand
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Effects of cannabidiol in animal models predictive of antipsychotic activity
The effects of cannabidiol (CBD) were compared to those produced by haloperidol in rats submitted to experimental models predictive of antipsychotic activity. Several doses of CBD (15–480 mg/kg) andExpand
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Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes
Diabetes is a chronic disease associated with depression whose pathophysiological mechanisms that associate these conditions are not fully elucidated. However, the activation of theExpand
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Extracellular serotonin level in the basolateral nucleus of the amygdala and dorsal periaqueductal gray under unconditioned and conditioned fear states: An in vivo microdialysis study
Serotonin (5-HT) plays a key role in the neural circuitry mediating unconditioned and conditioned fear responses related to panic and generalized anxiety disorders. The basolateral nucleus of theExpand
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Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia.
The effects of BK agonists and antagonists, and other hyperalgesic/antihyperalgesic drugs were measured (3 h after injection of hyperalgesic drugs) in a model of mechanical hyperalgesia (theExpand
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Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response
Thyme (Thymus vulgaris L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. TheExpand
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The critical role of leukotriene B4 in antigen‐induced mechanical hyperalgesia in immunised rats
We investigated the mediators responsible for mechanical hypersensitivity induced by antigen challenge in rats immunised with ovalbumin (OVA). Challenge with OVA (12.5–100 μg, intraplantar) caused aExpand
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Trypanosoma cruzi: both chemically induced and triatomine-derived metacyclic trypomastigotes cause the same immunological disturbances in the infected mammalian host.
Infection of BALB/c mice with chemically induced metacyclic forms of Trypanosoma cruzi clone Dm28c led to characteristic changes of experimental Chagas' disease, with protracted but markedExpand
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