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CI 1000
Known as:
CI-1000
National Institutes of Health
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Highly Cited
2002
Highly Cited
2002
Purine nucleoside phosphorylase as a cytosolic arsenate reductase.
Z. Gregus
,
B. Németi
Toxicological Sciences
2002
Corpus ID: 28577897
The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase…
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1995
1995
Subacute toxicity of a purine nucleoside phosphorylase inhibitor in rats.
G. Wolfgang
,
M. Bleavins
,
H. Hallak
,
O. Kasali
,
E. Urda
Fundamental and Applied Toxicology
1995
Corpus ID: 9346564
Rats received daily oral doses of 15, 50, 150, or 200 mg/kg CI-1000 for 4 weeks. Doses were selected based on findings from a 2…
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1994
1994
Pharmacokinetics/pharmacodynamics of CI-1000, a purine nucleoside phosphorylase (PNP) inhibitor, in rats and monkeys.
H. Hallak
,
A. Hayes
,
M. Dong
,
R. Gilbertsen
,
R. Guttendorf
Advances in Experimental Medicine and Biology
1994
Corpus ID: 30555432
Purine nucleoside Phosphorylase (PNP) is a purine salvage enzyme that catalyzes the reversible phosphorylation of guanine and…
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1994
1994
Blockade of nucleoside degradation in monkey whole blood in vitro by CI-1000, a purine nucleoside phosphorylase (PNP) inhibitor.
R. Gilbertsen
,
M. Dong
Advances in Experimental Medicine and Biology
1994
Corpus ID: 2371408
Purine nucleosides HxR or GdR (2.5 micrograms/mL blood) were added to EDTA-treated cynomolgus monkey whole blood in vitro, alone…
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1994
1994
Changes in monkey plasma purines induced by repeated doses of CI-1000, a novel inhibitor of purine nucleoside phosphorylase.
D. Robertson
,
E. Urda
,
M. Bleavins
,
N. Lalwani
Advances in Experimental Medicine and Biology
1994
Corpus ID: 43245106
CI-1000, a 9-deazaguanine analog, is an orally active and reversible inhibitor of purine nucleoside Phosphorylase (PNP). In vitro…
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1994
1994
Evidence for a Pathway Independent from 2′‐Deoxyguanosine and Reversible by IL‐2 by which Purine Nucleoside Phosphorylase Inhibitors Block T‐Cell Proliferation
W. Boehncke
,
R. Gilbertsen
,
J. Hemmer
,
W. Sterry
Scandinavian Journal of Immunology
1994
Corpus ID: 12342234
Patients with homozygous deficiency of purine nucleoside phosphorylase (PNP) present with a T‐cell selective immune deficiency…
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