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The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase… Expand Children with congenital homozygous deficiency of purine nucleoside phosphorylase (PNP) have abnormalities in purine metabolism… Expand Rats received daily oral doses of 15, 50, 150, or 200 mg/kg CI-1000 for 4 weeks. Doses were selected based on findings from a 2… Expand Purine nucleoside Phosphorylase (PNP) is a purine salvage enzyme that catalyzes the reversible phosphorylation of guanine and… Expand Purine nucleosides HxR or GdR (2.5 micrograms/mL blood) were added to EDTA-treated cynomolgus monkey whole blood in vitro, alone… Expand CI-1000, a 9-deazaguanine analog, is an orally active and reversible inhibitor of purine nucleoside Phosphorylase (PNP). In vitro… Expand Patients with homozygous deficiency of purine nucleoside phosphorylase (PNP) present with a T‐cell selective immune deficiency… Expand