Subacute toxicity of a purine nucleoside phosphorylase inhibitor in rats.

@article{Wolfgang1995SubacuteTO,
  title={Subacute toxicity of a purine nucleoside phosphorylase inhibitor in rats.},
  author={G. Wolfgang and M. Bleavins and H. Hallak and O. Kasali and E. Urda},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1995},
  volume={28 1},
  pages={
          51-8
        }
}
  • G. Wolfgang, M. Bleavins, +2 authors E. Urda
  • Published 1995
  • Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
Rats received daily oral doses of 15, 50, 150, or 200 mg/kg CI-1000 for 4 weeks. Doses were selected based on findings from a 2-week range-finding study where doses of 250 and 500 mg/kg resulted in mortality. In the 4-week study, females given 200 mg/kg were sacrificed during Week 2 due to poor condition. Serum creatinine and urea nitrogen increased 2- to 2.5-fold in females given 200 mg/kg. Dose-related increases in urine volume, urinary protein excretion, and osmolar excretion occurred in… Expand