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Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First‐ and Third‐generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations
TLDR
It is concluded that equivalent plasma drug concentrations and metabolic profiles can be expected for native Japanese, first‐ and third‐generation Japanese, Koreans, and Chinese for compounds handled through these six CYP enzymes. Expand
Polychlorinated biphenyls (Aroclors 1016 and 1242): Effects on survival and reproduction in mink and ferrets
TLDR
Ferrets were more resistant to the effects of either PCB mixture than were the mink, as noted by the lower mortality rate on the Aroclor 1242 diet and the almost normal level of reproduction on the Mink/Ferrets study, and this finding is in sharp contrast to the 100% mortality of adult mink fed the same level. Expand
Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury.
TLDR
The data suggest that endogenous TIMP-2 and SLPI dynamically regulate the intensity of lung inflammatory injury, doing so at least in part by affecting the generation of the inflammatory mediator, C5a. Expand
Effects of phenylhydrazine or phlebotomy on peripheral blood, bone marrow and erythropoietin in Wistar rats
TLDR
Flow cytometric differentials of rat bone marrow using 2,7‐dichlorofluorescin successfully predicted erythroid hyperplasia in both experimental groups and returned to normal within 14 days and the remaining CBC parameters were normal within 28 days for both treatment groups. Expand
Effects of supplemental dietary copper on growth, reproductive performance and kit survival of standard dark mink and the acute toxicity of copper to mink.
TLDR
The reproductive performance of mink on the longer term Cu supplementation was not adversely affected, although greater kit mortality and reduced "litter mass" were a result of the higher Cu concentrations. Expand
Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison
TLDR
Evidence is provided that supports the use of an ex vivo LLNA for hazard assessment of contact hypersensitivity, and measuring ex vivo 3H‐thymidine incorporation was more sensitive than evaluating lymph node weight and cellularity, and in vitro bromodeoxyuridine incorporation. Expand
Effects of excessive dietary zinc on the intrauterine and postnatal development of mink.
Dietary exposure to 1000 ppm of supplemental Zn did not result in grossly observable Zn toxicity or Zn-induced Cu deficiency in adult mink. These same concentrations did, however, produceExpand
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high‐density DNA microarrays
TLDR
This toxico genomic analysis identified multiple genes and groups of genes that were affected by the hepatotoxicants on study, indicating that high‐density microarray expression data are useful to identifygroups of genes involved in toxicity. Expand
Excessive nail growth in the European ferret induced by Aroclor 1242
TLDR
European ferrets fed a diet that contained 20 ppm Aroclor 1242 for several months developed elongated, thickened, and deformed toenails, more conspicuous in the males than in the females and was especially pronounced in the hind feet. Expand
BIOLOGICAL EFFECTS OF PCBs AND PBBs ON MINK AND FERRETS - A REVIEW
TLDR
PCBs transfer to the newborn via milk was greater than placental transfer and PBB was not as fetotoxic as PCBs but was lethal to the adult at a lower dietary concentration. Expand
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