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GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpanzees to induce clearance of HBV-infected cells and might be developed for treatment of patients with chronic HBV infection. Expand
Safety, Pharmacokinetics and Pharmacodynamics of Gs-9620, An Oral Toll-Like Receptor 7 Agonist
GS-9620 demonstrates safety and pharmacodynamic activity at doses up to 12 mg, suggesting the potential for induction of an antiviral response without systemic adverse events in subjects with chronic viral hepatitis. Expand
Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis
Cenicriviroc displayed potent anti-inflammatory and antifibrotic activity in a range of animal fibrosis models, supporting human testing for fibrotic diseases. Expand
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.
The data demonstrate that short duration, finite treatment with the oral TLR7 agonist GS-9620 can induce a sustained antiviral response in the woodchuck model of CHB, and support investigation of this compound as a therapeutic approach to attain a functional cure in CHB patients. Expand
In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine.
The D and L isomers of DCVC were both shown to be toxic, the toxicity assessed in vitro corresponded well with the toxicity in vivo. Expand
Critical subcellular targets of cisplatin and related platinum analogs in rat renal proximal tubule cells.
- M. Leibbrandt, G. Wolfgang, A. Metz, A. A. Ozobia, J. Haskins
- Biology, Medicine
- Kidney international
- 1 September 1995
Investigation of the mechanism of nephrotoxicity and the effects of platinum analogs on specific organelles and basal protein synthesis in rat renal proximal tubule cells confirmed that cisplatin's toxicity to RPTCs was delayed and cumulative. Expand
N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism.
- G. Wolfgang, A. J. Gandolfi, J. Stevens, K. Brendel
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 November 1989
N-Acetyl-DCVC produced dose- and time-dependent decreases in intracellular K+ content and lactate dehydrogenase activity and produced a lesion with similar intratubular specificity to that seen with DCVC, suggesting the S3 specificity seen in vivo could be produced by either compound. Expand
Antioxidant-dependent inhibition of diquat-induced toxicity in vivo.
The abilities of two experimental antioxidants, as well as the model antioxidant, diphenyl-p-phenylenediamine (DPPD), to protect against diquat-induced toxicity in male Fischer-344 rats were examined, suggesting that initiation of diqu at-induced hepatotoxicity is rapid and that these compounds would therefore be unlikely to have clinical utility in the treatment ofdiquat intoxication. Expand
Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses
- A. Fosdick, Jim Zheng, +5 authors D. Tumas
- Chemistry, Medicine
- The Journal of Pharmacology and Experimental…
- 1 January 2014
Oral administration of GS-9620 can induce an antiviral innate immune response without inducing a systemic IFN-α response, and the therapeutic potential of this approach in the treatment of chronic HBV infection is suggested. Expand
Hepatic and adrenal toxicity of a novel lipid regulator in beagle dogs.
- G. Wolfgang, D. Robertson, D. Welty, A. Metz
- Fundamental and applied toxicology : official…
Plasma concentrations of PD 131842-15 increased with increasing dose; plasma levels were significantly lower during Week 12 than those on Day 1, possibly due to autoinduction. Expand